| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
CHRM2 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus), Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
IHC-P, WB |
| Recommended dilutions: |
5-1ug/ml, 5-1ug/ml, IHC (Paraffin): 0, Western blot: 0 |
| Notes: |
Titration of the CHRM2 antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting amounts |
| Intented use: |
This CHRM2 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
P08172 |
| Purity: |
Antigen affinity |
| Description: |
Gosso MF et al, In a sample of 667 individuals from 304 families, In airway parasympathetic neurons, The CHRM2 gene inhibits the release of acetylcholine from cholinergic fibers in the lungs and elsewhere, The M2 muscarinic receptors are located in the heart, The protein is implicated in memory and cognition, This gene is though to be involved in neuronal excitability, Wang et al, also known as the cholinergic receptor, and its function is impaired in many neuropsychiatric disorders, by slowing the speed of depolarization, cited evidence of common and specific genetic effects: association of the muscarinic acetylcholine receptor M2 gene with alcohol dependence and major depressive syndrome, genotyped three single-nucleotide polymorphisms(SNPs) in the CHRM2 gene on 7q31-35, increasing actylcholine release, is a muscarinic acetylcholine receptor, it is decreased by viral infections and by interferon-gamma, muscarinic 2, synaptic plasticity and feedback regulation of acetylcholine release and has previously been implicated in higher cognitive processing, where they act to slow the heart rate down to normal sinus rhythm after stimulatory actions of the sympathetic nervous system, The muscarinic acetylcholine receptor M2 |
| Immunogen: |
mouse and rat), An amino acid sequence from the C-terminus of human CHRM2 (EKQNIVARKIVKMTK) was used as the immunogen for this CHRM2 antibody (100% homologous human |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long-term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the CHRM2 antibody can be stored for up to one month at 4oC, After reconstitution |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
CHRM2 |
| Short name: |
CHRM2 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
CHRM2 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
1951 |
| Gene: |
CHRM2 |
More about : CHRM2 |
| Long gene name: |
cholinergic receptor muscarinic 2 |
| Synonyms name: |
acetylcholine receptor, muscarinic 2 |
| Locus: |
7q33 |
| Discovery year: |
1988-08-04 |
| Entrez gene record: |
1129 |
| Classification: |
Cholinergic receptors muscarinic |
| Havana BLAST/BLAT: |
OTTHUMG00000155658 |
| Locus Specific Databases: |
LRG_405 |