| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
APOA1 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus), Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
WB |
| Recommended dilutions: |
5-1ug/ml, Western blot: 0 |
| Notes: |
Titration of the APOA1 antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting amounts |
| Intented use: |
This APOA1 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
P02647 |
| Purity: |
Antigen affinity |
| Description: |
APOA1 overexpression promotes macrophage-specific reverse cholesterol transport, APOA1 was also isolated as a prostacyclin(PGI2) stabilizing factor, Additionally, Defects in the gene encoding it are associated with HDL deficiencies, It binds to lipopolysaccharide or endotoxin, It is a cofactor for lecithin cholesterolacyltransferase(LCAT) which is responsible for the formation of most plasma cholesteryl esters, It is a single polypeptide chain with 243 amino acid residues of known primary amino acid sequence, The gene is mapped to 11q23, The protein promotes cholesterol efflux from tissues to the liver for excretion, and has a major role in the anti-endotoxin function of HDL, and thus may have an anticlotting effect, and with systemic non-neuropathic amyloidosis, including Tangier disease, Apolipoprotein A I is a human protein with a specific role in lipid metabolism |
| Immunogen: |
mouse and rat), An amino acid sequence from the N-terminus of human Apolipoprotein A I (YVDVLKDSGRDYVSQFE) was used as the immunogen for this APOA1 antibody (100% homologous in human |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long-term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the APOA1 antibody can be stored for up to one month at 4oC, After reconstitution |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
APOA1 |
| Short name: |
APOA1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
apolipoprotein A-I (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
APOA1 and IDBG-630796 and ENSBTAG00000002258 and 281631, APOA1 and IDBG-72644 and ENSG00000118137 and 335, Apoa1 and IDBG-161189 and ENSMUSG00000032083 and 11806, lipoprotein particle binding, nuclei, this GO :0001523 and retinoid metabolic process and biological process this GO :0001540 and beta-amyloid binding and molecular function this GO :0001932 and regulation of protein phosphorylation and biological process this GO :0001935 and endothelial cell proliferation and biological process this GO :0002576 and platelet degranulation and biological process this GO :0002740 and negative regulation of cytokine secretion involved in immune response and biological process this GO :0005319 and lipid transporter activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005543 and phospholipid binding and molecular function this GO :0005548 and phospholipid transporter activity and molecular function this GO :0005576 and extracellular region and cellular component this GO :0005615 and extracellular space and cellular component this GO :0005634 and nucleus and cellular component this GO :0005769 and early endosome and cellular component this GO :0005788 and endoplasmic reticulum lumen and cellular component this GO :0005829 and cytosol and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0006644 and phospholipid metabolic process and biological process this GO :0006656 and phosphatidylcholine biosynthetic process and biological process this GO :0006695 and cholesterol biosynthetic process and biological process this GO :0006869 and lipid transport and biological process this GO :0007186 and G-protein coupled receptor signaling pathway and biological process this GO :0007584 and response to nutrient and biological process this GO :0007596 and blood coagulation and biological process this GO :0007603 and phototransduction, this GO :0001540 : beta-amyloid binding, this GO :0001540 : beta-amyloid binding and also this GO :0005319 : lipid transporter activity and also this GO :0005515 : protein binding and also this GO :0005543 : phospholipid binding and also this GO :0005548 : phospholipid transporter activity and also this GO :0008035 : high-density lipoprotein particle binding and also this GO :0008289 : lipid binding and also this GO :0015485 : cholesterol binding and also this GO :0017127 : cholesterol transporter activity and also this GO :0019899 : enzyme binding and also this GO :0034190 : apolipoprotein receptor binding and also this GO :0034191 : apolipoprotein A-I receptor binding and also this GO :0042802 : identical protein binding and also this GO :0055102 : lipase inhibitor activity and also this GO :0060228 : phosphatidylcholine-sterol O-acyltransferase activator activity and also this GO :0070653 : high-density lipoprotein particle receptor binding and also this GO :0071813 : lipoprotein particle binding, this GO :0005319 : lipid transporter activity, this GO :0005515 : protein binding, this GO :0005543 : phospholipid binding, this GO :0005548 : phospholipid transporter activity, this GO :0008035 : high-density lipoprotein particle binding, this GO :0008289 : lipid binding, this GO :0015485 : cholesterol binding, this GO :0017127 : cholesterol transporter activity, this GO :0019899 : enzyme binding, this GO :0034190 : apolipoprotein receptor binding, this GO :0034191 : apolipoprotein A-I receptor binding, this GO :0042802 : identical protein binding, this GO :0055102 : lipase inhibitor activity, this GO :0060228 : phosphatidylcholine-sterol O-acyltransferase activator activity, this GO :0070653 : high-density lipoprotein particle receptor binding, this GO :0071813 : lipoprotein particle binding, visible light and biological process this GO :0008035 and high-density lipoprotein particle binding and molecular function this GO :0008203 and cholesterol metabolic process and biological process this GO :0008211 and glucocorticoid metabolic process and biological process this GO :0008289 and lipid binding and molecular function this GO :0009986 and cell surface and cellular component this GO :0010804 and negative regulation of tumor necrosis factor-mediated signaling pathway and biological process this GO :0010873 and positive regulation of cholesterol esterification and biological process this GO :0010903 and negative regulation of very-low-density lipoprotein particle remodeling and biological process this GO :0014012 and peripheral nervous system axon regeneration and biological process this GO :0015485 and cholesterol binding and molecular function this GO :0015914 and phospholipid transport and biological process this GO :0017127 and cholesterol transporter activity and molecular function this GO :0018158 and protein oxidation and biological process this GO :0018206 and peptidyl-methionine modification and biological process this GO :0019899 and enzyme binding and molecular function this GO :0019915 and lipid storage and biological process this GO :0030139 and endocytic vesicle and cellular component this GO :0030168 and platelet activation and biological process this GO :0030300 and regulation of intestinal cholesterol absorption and biological process this GO :0030301 and cholesterol transport and biological process this GO :0030325 and adrenal gland development and biological process this GO :0031100 and organ regeneration and biological process this GO :0031410 and cytoplasmic vesicle and cellular component this GO :0032489 and regulation of Cdc42 protein signal transduction and biological process this GO :0033344 and cholesterol efflux and biological process this GO :0033700 and phospholipid efflux and biological process this GO :0034115 and negative regulation of heterotypic cell-cell adhesion and biological process this GO :0034190 and apolipoprotein receptor binding and molecular function this GO :0034191 and apolipoprotein A-I receptor binding and molecular function this GO :0034361 and very-low-density lipoprotein particle and cellular component this GO :0034364 and high-density lipoprotein particle and cellular component this GO :0034365 and discoidal high-density lipoprotein particle and cellular component this GO :0034366 and spherical high-density lipoprotein particle and cellular component this GO :0034375 and high-density lipoprotein particle remodeling and biological process this GO :0034380 and high-density lipoprotein particle assembly and biological process this GO :0034384 and high-density lipoprotein particle clearance and biological process this GO :0034774 and secretory granule lumen and cellular component this GO :0042157 and lipoprotein metabolic process and biological process this GO :0042158 and lipoprotein biosynthetic process and biological process this GO :0042493 and response to drug and biological process this GO :0042632 and cholesterol homeostasis and biological process this GO :0042802 and identical protein binding and molecular function this GO :0043534 and blood vessel endothelial cell migration and biological process this GO :0043627 and response to estrogen and biological process this GO :0043691 and reverse cholesterol transport and biological process this GO :0044255 and cellular lipid metabolic process and biological process this GO :0044281 and small molecule metabolic process and biological process this GO :0045087 and innate immune response and biological process this GO :0050713 and negative regulation of interleukin-1 beta secretion and biological process this GO :0050728 and negative regulation of inflammatory response and biological process this GO :0050821 and protein stabilization and biological process this GO :0051345 and positive regulation of hydrolase activity and biological process this GO :0051346 and negative regulation of hydrolase activity and biological process this GO :0051347 and positive regulation of transferase activity and biological process this GO :0055085 and transmembrane transport and biological process this GO :0055091 and phospholipid homeostasis and biological process this GO :0055102 and lipase inhibitor activity and molecular function this GO :0060192 and negative regulation of lipase activity and biological process this GO :0060228 and phosphatidylcholine-sterol O-acyltransferase activator activity and molecular function this GO :0060354 and negative regulation of cell adhesion molecule production and biological process this GO :0060761 and negative regulation of response to cytokine stimulus and biological process this GO :0070062 and extracellular vesicular exosome and cellular component this GO :0070328 and triglyceride homeostasis and biological process this GO :0070508 and cholesterol import and biological process this GO :0070653 and high-density lipoprotein particle receptor binding and molecular function this GO :0071682 and endocytic vesicle lumen and cellular component this GO :0071813 and lipoprotein particle binding and molecular function this GO :0072562 and blood microparticle and cellular component, apolipoprotein A-I |
| Identity: |
600 |
| Gene: |
APOA1 |
More about : APOA1 |
| Long gene name: |
apolipoprotein A1 |
| Synonyms gene name: |
apolipoprotein A-I |
| Locus: |
11q23, 3 |
| Discovery year: |
2001-06-22 |
| GenBank acession: |
X02162 |
| Entrez gene record: |
335 |
| RefSeq identity: |
NM_000039 |
| Classification: |
Apolipoproteins |
| Havana BLAST/BLAT: |
OTTHUMG00000046112 |
| Locus Specific Databases: |
LRG_767 |