| Gene info: |
A serine/threonine protein kinase associated with IL-1 receptor (IRAK) and its homologue mouse pelle-like protein kinase (mPLK) were identified recently, IRAK is associated with the IL-1 receptor subunits IL-1RI and IL-1RAcP after IL-1 binding and serves as a signaling molecule to mediate IL-1 response, IRAK mediates a signaling cascade leading to NF-kB activation by members in IL-1 family including IL-1 and a novel cytokine IL-18 (also termed IGIF), NF-kB mediates the expression of a great variety of genes in response to extracellular stimuli including IL-1, TNFalpha and LPS, IRAK Monoclonal Antibody: Nuclear factor kappa B (NF-kappaB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses |
| Gene names: |
pelle, IRAK Antibody [1F12C1] : IRAK |
| Antibodie's label: |
unlabelled serum |
| Purity: |
IRAK Monoclonal Antibody is immunoaffinity chromotography purified IgG |
| Ab raised in: |
Mouse |
| Type: |
Monoclonal |
| Monoclonal: |
1F12C1 |
| Immunoglobulin: |
IgG1 |
| Antigen: |
Recombinant protein corresponding to amino acids 618 - 712 of human IRAK |
| Immuno application: |
Western Blot, immuno-histo-chemistry, ELISA |
| Antibody advice: |
Antibody can also be used for immunohistochemistry starting at 2, 5 ug/mL, RAK antibody can be used for Western blot at 1 - 2 ug/mL |
| Suspention, pH, azide: |
02% sodium azide, IRAK Monoclonal Antibody is supplied in PBS containing 0 |
| Keep at: |
stable for one year, IRAK monoclonal antibody can be stored at -20 grades C |
| Works with: |
Mouse, Human |
| Omim nr: |
8928535 |
| Ncbi nr: |
P51617 |
| Vial with antibody: |
in solution |
| Quantity per ml: |
1 mg/mL |
| NCBI GENE nr: |
3654 |
| GENE symbol: |
IRAK1 |
| Antigene name: |
interleukin-1 receptor-associated kinase 1 |
| Source: |
homo sapiens |
| Protein nr: |
P51617 |
| Description: |
Freeze thaw will destroy a percentage in every cycle and should be avoided, C in a fridge short term in a concentrated dilution, This antibody needs to be stored at + 4° |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by proscience they should be stored frozen at - 24° |
| Gene target: |
IRAK [1F12C1] |
| Short name: |
anti-IRAK Antibody [1F12C1] |
| Technique: |
antibodies against human proteins, antibodies for, antibody to, Antibody |
| Alternative name: |
antibody to-IRAK (Antibody to) [1F12C1] |
| Alternative technique: |
antibodies |
| Identity: |
6112 |
| Gene: |
IRAK1 |
More about : IRAK1 |
| Long gene name: |
interleukin 1 receptor associated kinase 1 |
| Synonyms: |
IRAK pelle |
| Locus: |
Xq28 |
| Discovery year: |
1998-06-22 |
| GenBank acession: |
L76191 |
| Entrez gene record: |
3654 |
| Pubmed identfication: |
9374458 8599092 |
| Havana BLAST/BLAT: |
OTTHUMG00000024228 |
| Locus Specific Databases: |
Mental Retardation database |