| Also known as: |
CD35 |
| Other names: |
C3-binding protein, C3b/C4b receptor, C3b/C4b receptor, CD35 antigen, CD_antigen: CD35, Complement receptor type 1, Knops blood group antigen, complement component (3b/4b) receptor 1 (Knops blood group), complement receptor type 1, complement receptor type 1 isoform F |
| Category: |
Antibodies |
| Subcategory: |
Mnoclonal antibodies |
| Gene name: |
CR1 |
| Other gene names: |
C3BR, C3BR, C4BR, CD35, CR1, KN, CR1 |
| Clonality: |
Monoclonal |
| Immunoglobulin isotype: |
kappa, IgG1 |
| Clone: |
E11 |
| Host organism: |
Mouse (Mus musculus) |
| Species reactivity: |
Baboon, Cynomolgus Monkey, Due to limited knowledge and inability for testing each and every species, Rhesus Monkey, the reactivity of the antibody may extend to other species which are not listed hereby, Human (Homo sapiens) |
| Specificity and cross-reactivity: |
Follicular dendritic cells (FDC) are restricted to the B-cell regions of secondary lymphoid follicles, Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, The Knops blood group system is a system of antigens located on this protein, The primary function of CR1 is to serve as the cellular receptor for C3b and C4b, They are CD21+/CD35+/CD1a-, This MAb is highly specific to CR1 and shows no cross-reaction with CR2, This MAb is specific for a site in CR1 that is distal from the C3b-binding site, This MAb labels follicular dendritic cells and follicular dendritic cell sarcoma, This particular antibody might cross react with speacies outside of the listed ones, so that it is unable to block CR1 activity, the most important components of the complement system leading to clearance of foreign macromolecules, which is identified as the complement receptor 1 (CR1)/CD35, Recognizes a protein of 210-220kDa |
| Storage and shipping: |
Antibody is stable for 24 months, Temperature variations in the range of 1 to 7 degrees Celsius are tolerable, We recommend NOT to freeze the antibody, Store the antibody at +4C |
| Tested applications:: |
Flow Cytometry (FC/FACS), Immunofluorescence (IF), Immunohistology (IH), Immunoprecipitation (IP), Western Blot (WB), ELISA (EIA) |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by MBS mono they should be stored frozen at - 24° |
| Gene target: |
CD35/ CR1 |
| Short name: |
CD35/ CR1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
CD35/ complement component (3b/4b) receptor 1 (Knops blood group) (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
C3BR and C4BR and CD35 and KN, CR1 and IDBG-106358 and ENSG00000203710 and 1378, Cell surfaces, alternative pathway and biological process this GO :0045959 and negative regulation of complement activation, classical pathway and biological process this GO :0009986 and cell surface and cellular component this GO :0030449 and regulation of complement activation and biological process this GO :0045087 and innate immune response and biological process this GO :0045957 and negative regulation of complement activation, classical pathway and biological process this GO :0070062 and extracellular vesicular exosome and cellular component this GO :1900004 and negative regulation of serine-type endopeptidase activity and biological process this GO :1900005 and positive regulation of serine-type endopeptidase activity and biological process, complement component C3b receptor activity, this GO :0001851 and complement component C3b binding and molecular function this GO :0001855 and complement component C4b binding and molecular function this GO :0001861 and complement component C4b receptor activity and molecular function this GO :0002430 and complement receptor mediated signaling pathway and biological process this GO :0004877 and complement component C3b receptor activity and molecular function this GO :0005886 and plasma membrane and cellular component this GO :0005887 and integral component of plasma membrane and cellular component this GO :0006958 and complement activation, this GO :0001851 : complement component C3b binding, this GO :0001851 : complement component C3b binding and also this GO :0001855 : complement component C4b binding and also this GO :0001861 : complement component C4b receptor activity and also this GO :0004877 : complement component C3b receptor activity, this GO :0001855 : complement component C4b binding, this GO :0001861 : complement component C4b receptor activity, this GO :0004877 : complement component C3b receptor activity, complement component (3b/4b) receptor 1 (Knops blood group) |
| Identity: |
2334 |
| Gene: |
CR1 |
More about : CR1 |
| Long gene name: |
complement C3b/C4b receptor 1 (Knops blood group) |
| Synonyms gene name: |
complement component (3b/4b) receptor 1, including Knops blood group system complement component (3b/4b) receptor 1 (Knops blood group) complement component 3b/4b receptor 1 (Knops blood group) |
| Synonyms: |
CD35 KN |
| Locus: |
1q32, 2 |
| Discovery year: |
2001-06-22 |
| GenBank acession: |
Y00816 |
| Entrez gene record: |
1378 |
| Pubmed identfication: |
1708809 |
| RefSeq identity: |
NM_000573 |
| Classification: |
Sushi domain containing Complement system CD molecules Blood group antigens |
| Havana BLAST/BLAT: |
OTTHUMG00000036311 |
| Locus Specific Databases: |
Blood Group Antigen Mutation Database LRG_814 |