| Also known as: |
gp100 |
| Other names: |
ME20-M, ME20-S, ME20M, ME20S, Melanocyte protein PMEL, Melanocyte protein Pmel 17, Melanocytes lineage-specific antigen GP100, Melanoma-associated ME20 antigen, P1, P100, P26, Premelanosome protein, Secreted melanoma-associated ME20 antigen, Silver locus protein homologCleaved into the following 2 chains:M-alphaAlternative name(s):95 kDa melanocyte-specific secreted glycoprotein, homolog of, melanocyte protein PMEL, melanocyte protein Pmel 17, melanocyte protein mel 17, melanocytes lineage-specific antigen GP100, melanoma-associated ME20 antigen, melanosomal matrix protein17, mouse, premelanosome protein, silver, silver locus protein homolog, melanocyte protein PMEL isoform 2 |
| Category: |
Antibodies |
| Subcategory: |
Mnoclonal antibodies |
| Gene name: |
SILV |
| Other gene names: |
D12S53E, D12S53E, ME20, ME20-M, ME20-S, ME20M, ME20M, ME20S, P1, P100, PMEL, PMEL17, PMEL17, SI, SIL, SILV, SILV, gp100, PMEL |
| Clonality: |
Monoclonal |
| Immunoglobulin isotype: |
kappa, IgG1 |
| Clone: |
HMB45 |
| Host organism: |
Mouse (Mus musculus) |
| Species reactivity: |
Does not react with dog and Rat (Rattus norvegicus), Due to limited knowledge and inability for testing each and every species, Others-not tested, the reactivity of the antibody may extend to other species which are not listed hereby, Human (Homo sapiens) |
| Specificity and cross-reactivity: |
Anti-HMB-45 stains fetal and neonatal melanocytes, E stains alone, Intradermal nevi, It does not stain tumor cells of epithelial, It is also difficult to differentiate melanoma from spindle cell carcinomas and various types of mesenchymal neoplasms, Metastatic amelanotic melanoma can often be confused with a variety of poorly differentiated carcinomas, Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, This MAb also stains Angiomyolipoma (PEComa), This MAb reacts with junctional and blue nevus cells and variably with fetal and neonatal melanocytes, This particular antibody might cross react with speacies outside of the listed ones, and malignant melanoma, and non-melanocytic cells are negative, and sarcomas using H &, glial, it specifically recognizes a protein in melanocytes and melanomas, junctional and blue nevus cells, large cell lymphomas, lymphoid, normal adult melanocytes, or mesenchymal origin, By immunohistochemistry |
| Storage and shipping: |
Antibody is stable for 24 months, Temperature variations in the range of 1 to 7 degrees Celsius are tolerable, We recommend NOT to freeze the antibody, Store the antibody at +4C |
| Tested applications:: |
Immunofluorescence (IF), Immunohistology (IH), Immunoprecipitation (IP), Western Blot (WB), Flow Cytometry (FC/FACS) |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by MBS mono they should be stored frozen at - 24° |
| Gene target: |
gp100/ Melanosome/ PMEL17/ SILV |
| Short name: |
gp100/ Melanosome/ PMEL17/ SILV Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
gp100/ Melanosome/ PMEL17/ SILV (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
10880 |
| Gene: |
PMEL |
More about : PMEL |
| Long gene name: |
premelanosome protein |
| Synonyms gene: |
SIL SILV |
| Synonyms gene name: |
silver (mouse homolog) like silver homolog (mouse) |
| Synonyms: |
D12S53E SI Pmel17 gp100 |
| Locus: |
12q13, 2 |
| Discovery year: |
1997-06-24 |
| GenBank acession: |
AK092881 |
| Entrez gene record: |
6490 |
| Pubmed identfication: |
8739560 |
| RefSeq identity: |
NM_006928 |
| Havana BLAST/BLAT: |
OTTHUMG00000170573 |