| Also known as: |
CR1 / CD35 |
| Other names: |
C3-binding protein, C3b/C4b receptor, C3b/C4b receptor, CD35 antigen, CD_antigen: CD35, Complement receptor type 1, Knops blood group antigen, complement component (3b/4b) receptor 1 (Knops blood group), complement receptor type 1, complement receptor type 1 isoform S |
| Category: |
Antibodies |
| Subcategory: |
Mnoclonal antibodies |
| Gene name: |
CR1 |
| Gene name synonims: |
CD35 |
| Other gene names: |
C3BR, C3BR, C4BR, CD35, CR1, KN, CR1 |
| Clonality: |
Monoclonal |
| Immunoglobulin isotype: |
IgG1 |
| Clone: |
E11 |
| Host organism: |
Mouse (Mus musculus) |
| Species reactivity: |
Baboon, Due to limited knowledge and inability for testing each and every species, Human (Homo sapiens), Rhesus monkey, the reactivity of the antibody may extend to other species which are not listed hereby, Cynomolgus monkey |
| Specificity and cross-reactivity: |
160kD and 250kD respectively, 220kD, B, B cells and some T cells, C, Clone E11 has been reported to be suitable for use in Western Blot, D) of 190kD, Functionally CD35 acts as a receptor for the C3b component of complement, Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, The molecule is expressed by granulocytes, This particular antibody might cross react with speacies outside of the listed ones, a single chain cell surface glycoprotein which exists in four allotypic forms (A, monocytes, Recognizes CD35 |
| Purification method: |
Protein A Purified |
| Form/Appearance: |
0, pH 7, 09% sodium azide, 4, PBS |
| Concentration: |
1 miligram per 1 mililiter |
| Storage and shipping: |
For long term storage aliquot and keep the antibody at -20 degrees Celsius, Freeze-thaw cycles should be avoided in order to retain the activity of the antibody, Store at +4 degrees Celsius for short term storage |
| Tested applications:: |
Flow Cytometry (FC/FACS), IHC - Frozen), Western Blot (WB), Immunohistochemistry (IHC - Paraffin |
| Properties: |
Depending on the epitopes used human ELISA kits can be cross reactive to many other species, Human proteins, Mainly analyzed are human serum, Modern , cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies, human cell culture supernatants and biological samples, plasma, primarily , saliva, urine, , (Homo sapiens, C, C for long term storage and for short term at + 5°, Homo sapiens sapiens), If you buy Antibodies supplied by MBS mono they should be stored frozen at - 24°, humans , ssp |
| About: |
Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones |
| Test: |
A/J, BALB/c, Mouse are mature after 40 days for females and 55 days for males, SCID while the CD-1 is outbred as strain, The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year, Transgenic, congenic and inbread strains are known for C57BL/6, knock-out, Mouse , mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab, or |
| Latin name: |
Mus musculus |
| Gene target: |
Monoclonal [ E11] (IgG1) CR1 / CD35 |
| Short name: |
Mouse Monoclonal [clone E11] (IgG1) CR1 / CD35 Antibody |
| Technique: |
Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, mouses, Antibody |
| Isotype: |
IgG1 |
| Species: |
Humans, Mouses, Human |
| Alternative name: |
sapiens complement component (3b/4b) receptor 1 (Knops blood group) / CD35 (Antibody to), Mouse monoclonal [clonality E11] (IgG1) to H |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
C3BR and C4BR and CD35 and KN, CR1 and IDBG-106358 and ENSG00000203710 and 1378, Cell surfaces, alternative pathway and biological process this GO :0045959 and negative regulation of complement activation, classical pathway and biological process this GO :0009986 and cell surface and cellular component this GO :0030449 and regulation of complement activation and biological process this GO :0045087 and innate immune response and biological process this GO :0045957 and negative regulation of complement activation, classical pathway and biological process this GO :0070062 and extracellular vesicular exosome and cellular component this GO :1900004 and negative regulation of serine-type endopeptidase activity and biological process this GO :1900005 and positive regulation of serine-type endopeptidase activity and biological process, complement component C3b receptor activity, this GO :0001851 and complement component C3b binding and molecular function this GO :0001855 and complement component C4b binding and molecular function this GO :0001861 and complement component C4b receptor activity and molecular function this GO :0002430 and complement receptor mediated signaling pathway and biological process this GO :0004877 and complement component C3b receptor activity and molecular function this GO :0005886 and plasma membrane and cellular component this GO :0005887 and integral component of plasma membrane and cellular component this GO :0006958 and complement activation, this GO :0001851 : complement component C3b binding, this GO :0001851 : complement component C3b binding and also this GO :0001855 : complement component C4b binding and also this GO :0001861 : complement component C4b receptor activity and also this GO :0004877 : complement component C3b receptor activity, this GO :0001855 : complement component C4b binding, this GO :0001861 : complement component C4b receptor activity, this GO :0004877 : complement component C3b receptor activity, complement component (3b/4b) receptor 1 (Knops blood group) |
| Identity: |
2334 |
| Gene: |
CR1 |
More about : CR1 |
| Long gene name: |
complement C3b/C4b receptor 1 (Knops blood group) |
| Synonyms gene name: |
complement component (3b/4b) receptor 1, including Knops blood group system complement component (3b/4b) receptor 1 (Knops blood group) complement component 3b/4b receptor 1 (Knops blood group) |
| Synonyms: |
CD35 KN |
| Locus: |
1q32, 2 |
| Discovery year: |
2001-06-22 |
| GenBank acession: |
Y00816 |
| Entrez gene record: |
1378 |
| Pubmed identfication: |
1708809 |
| RefSeq identity: |
NM_000573 |
| Classification: |
Sushi domain containing Complement system CD molecules Blood group antigens |
| Havana BLAST/BLAT: |
OTTHUMG00000036311 |
| Locus Specific Databases: |
Blood Group Antigen Mutation Database LRG_814 |