| Also known as: |
CD276 / B7-H3 |
| Other names: |
4Ig-B7-H3, B7 homolog 3, B7 homolog 3, B7-H3, CD276 antigen, CD276 antigen, CD276 molecule, CD_antigen: CD276, Costimulatory molecule, costimulatory molecule, CD276 antigen isoform b |
| Category: |
Antibodies |
| Subcategory: |
Mnoclonal antibodies |
| Gene name: |
CD276 |
| Gene name synonims: |
B7-H3 |
| Other gene names: |
4Ig-B7-H3, B7-H3, B7-H3, B7H3, B7H3, B7RP-2, CD276, CD276 |
| Clonality: |
Monoclonal |
| Immunoglobulin isotype: |
IgG1 |
| Clone: |
MIH42 |
| Host organism: |
Mouse (Mus musculus) |
| Species reactivity: |
Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby, Human (Homo sapiens) |
| Specificity and cross-reactivity: |
CD276 exists as two isoforms which result from gene duplication and differential splicing, CD276 is a type I transmembrane protein that induces the proliferation of CD4+ and CD8+ T cells, CD276 is reported to have therapeutic potential for the regulation of cell-mediated immune responses to cancer, Expression of CD276 can be induced on dendritic cells and monocytes by inflammatory cytokines, In humans, Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, This particular antibody might cross react with speacies outside of the listed ones, a member of the B7 family of co-stimulatory molecules also known as B7-H3, and is also widely expressed in peripheral tissues including the heart, enhances the generation of cytotoxic T cells and selectively stimulates the production of interferon gamma, kidney, particularly in conjunction with anti-angiogenic therapy, testis and colon, Detects CD276 |
| Purification method: |
Affinity Purified |
| Form/Appearance: |
0, 09% sodium azide, PBS |
| Concentration: |
1 miligram per 1 mililiter |
| Storage and shipping: |
Cycles of freezing and defrosting may denaturate the polypeptide chains of the antibodies and reduce their activity, For longer storage the antibody should be kept at -20 degrees Celsius, For short term storage keep the antibody at +4 degrees Celsius |
| Tested applications:: |
Flow Cytometry (FC/FACS), IHC - Frozen), Immunohistochemistry (IHC - Paraffin |
| Properties: |
Depending on the epitopes used human ELISA kits can be cross reactive to many other species, Human proteins, Mainly analyzed are human serum, Modern , cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies, human cell culture supernatants and biological samples, plasma, primarily , saliva, urine, , (Homo sapiens, C, C for long term storage and for short term at + 5°, Homo sapiens sapiens), If you buy Antibodies supplied by MBS mono they should be stored frozen at - 24°, humans , ssp |
| About: |
Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones |
| Test: |
A/J, BALB/c, Mouse are mature after 40 days for females and 55 days for males, SCID while the CD-1 is outbred as strain, The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year, Transgenic, congenic and inbread strains are known for C57BL/6, knock-out, Mouse , mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab, or |
| Latin name: |
Mus musculus |
| Gene target: |
Monoclonal [ MIH42] (IgG1) CD276 / B7-H3 |
| Short name: |
Mouse Monoclonal [clone MIH42] (IgG1) CD276 / B7-H3 Antibody |
| Technique: |
Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, mouses, Antibody |
| Isotype: |
IgG1 |
| Species: |
Humans, Mouses, Human |
| Alternative name: |
sapiens CD276 molecule / B7-H3 (Antibody to), Mouse monoclonal [clonality MIH42] (IgG1) to H |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
CD276 and IDBG-21197 and ENSG00000103855 and 80381, CD276 and IDBG-645646 and ENSBTAG00000019734 and 508656, Cd276 and IDBG-172080 and ENSMUSG00000035914 and 102657, Cell surfaces, protein binding, this GO :0005102 and receptor binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0006955 and immune response and biological process this GO :0008283 and cell proliferation and biological process this GO :0009897 and external side of plasma membrane and cellular component this GO :0016021 and integral component of membrane and cellular component this GO :0030501 and positive regulation of bone mineralization and biological process this GO :0042102 and positive regulation of T cell proliferation and biological process this GO :0042110 and T cell activation and biological process this GO :0042130 and negative regulation of T cell proliferation and biological process this GO :0045077 and negative regulation of interferon-gamma biosynthetic process and biological process this GO :0045078 and positive regulation of interferon-gamma biosynthetic process and biological process this GO :0045085 and negative regulation of interleukin-2 biosynthetic process and biological process this GO :0045669 and positive regulation of osteoblast differentiation and biological process this GO :0050728 and negative regulation of inflammatory response and biological process this GO :0050776 and regulation of immune response and biological process this GO :0070062 and extracellular vesicular exosome and cellular component this GO :1900042 and positive regulation of interleukin-2 secretion and biological process, this GO :0005102 : receptor binding, this GO :0005102 : receptor binding and also this GO :0005515 : protein binding, this GO :0005515 : protein binding, CD276 molecule |
| Identity: |
19137 |
| Gene: |
CD276 |
More about : CD276 |
| Long gene name: |
CD276 molecule |
| Synonyms gene name: |
CD276 antigen |
| Synonyms: |
B7-H3 B7H3 B7RP-2 |
| Locus: |
15q24, 1 |
| Discovery year: |
2005-03-04 |
| GenBank acession: |
AF302102 |
| Entrez gene record: |
80381 |
| Pubmed identfication: |
11224528 12055244 |
| RefSeq identity: |
NM_025240 |
| Classification: |
C2-set domain containing CD molecules V-set domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000137585 |