| Also known as: |
CHEMR23 / CMKLR1 |
| Other names: |
Chemokine-like receptor 1, Dez, G-protein coupled receptor ChemR23, G-protein coupled receptor ChemR23, G-protein coupled receptor DEZ, G-protein coupled receptor DEZ, chemerin receptor, chemokine receptor-like 1, chemokine-like receptor 1, chemokine-like receptor 1, orphan G-protein coupled receptor, resolvin E1 receptor, chemokine-like receptor 1 isoform b |
| Category: |
Antibodies |
| Subcategory: |
Mnoclonal antibodies |
| Gene name: |
CHEMR23 |
| Gene name synonims: |
CMKLR1 |
| Other gene names: |
CHEMERINR, CHEMR23, CMKLR1, ChemR23, DEZ, DEZ, RVER1, CMKLR1 |
| Clonality: |
Monoclonal |
| Immunoglobulin isotype: |
IgG2a |
| Clone: |
BZ332 |
| Host organism: |
Rat (Rattus norvegicus) |
| Species reactivity: |
Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby, Human (Homo sapiens) |
| Specificity and cross-reactivity: |
CMKLR1 is expressed on plasmacytoid dendritic cells (pDC) in blood but is not expressed on myeloid dendritic cells, Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, Studies show that CMKLR1 is also expressed on dendritic cells, Studies suggest that chemerin, The sole ligand for CMKLR1 is chemerin, This particular antibody might cross react with speacies outside of the listed ones, a chemoattractant that exists at the mRNA level in a wide range of tissues, a novel chemoattractant receptor, and as an inactive proform in serum and plasma, in plasma, is converted into a potent pDC attractant following blood coagulation and may be a process by which pDC's are recruited to sites of bleeding and tissue damage, lymphocytes, monocytes or granulocytes, which have been generated in vitro from monocytes, which is also referred to Chem23 or DEZ, Recognizes human serpentine chemokine-like receptor 1 (CMKLR1) |
| Purification method: |
Protein G Purified |
| Form/Appearance: |
0, pH 7, 09% sodium azide, 4, PBS |
| Concentration: |
1 miligram per 1 mililiter |
| Storage and shipping: |
Cycles of freezing and defrosting may denaturate the polypeptide chains of the antibodies and reduce their activity, For longer storage the antibody should be kept at -20 degrees Celsius, For short term storage keep the antibody at +4 degrees Celsius |
| Tested applications:: |
Flow Cytometry (FC/FACS), Immunohistochemistry (IHC - Paraffin) |
| Properties: |
Depending on the epitopes used human ELISA kits can be cross reactive to many other species, Human proteins, Mainly analyzed are human serum, Modern , cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies, human cell culture supernatants and biological samples, plasma, primarily , saliva, urine, , (Homo sapiens, C, C for long term storage and for short term at + 5°, Homo sapiens sapiens), If you buy Antibodies supplied by MBS mono they should be stored frozen at - 24°, humans , ssp |
| About: |
Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Rats are used to make rat monoclonal anti mouse antibodies, Rats , There are less rat- than mouse clones however, Monoclonals of this antigen are available in different clones, Rattus norvegicus are often studied in vivo as a model of human genes in Sprague-Dawley or Wistar rats, genes from rodents , of the genus |
| Latin name: |
Rattus norvegicus |
| Gene target: |
Monoclonal [ BZ332] (IgG2a) CHEMR23 / CMKLR1 |
| Short name: |
Monoclonal [clone BZ332] (IgG2a) CHEMR23 / CMKLR1 Antibody |
| Technique: |
Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, Antibody |
| Host: |
Rat |
| Isotype: |
IgG2a |
| Species: |
Humans, Rats, Human |
| Alternative name: |
sapiens CHEMR23 / chemokine-like receptor 1 (Antibody to), Rat monoclonal [clonality BZ332] (IgG2a) to H |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
CHEMERINR and ChemR23 and DEZ and RVER1, CMKLR1 and IDBG-55274 and ENSG00000174600 and 1240, CMLKR1 and IDBG-647886 and ENSBTAG00000022039 and 615411, Cmklr1 and IDBG-191760 and ENSMUSG00000042190 and 14747, Plasma membranes, protein binding, this GO :0001501 and skeletal system development and biological process this GO :0004872 and receptor activity and molecular function this GO :0004930 and G-protein coupled receptor activity and molecular function this GO :0004950 and chemokine receptor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005886 and plasma membrane and cellular component this GO :0005887 and integral component of plasma membrane and cellular component this GO :0006935 and chemotaxis and biological process this GO :0006955 and immune response and biological process this GO :0007186 and G-protein coupled receptor signaling pathway and biological process this GO :0010759 and positive regulation of macrophage chemotaxis and biological process this GO :0016021 and integral component of membrane and cellular component this GO :0032088 and negative regulation of NF-kappaB transcription factor activity and biological process this GO :0032695 and negative regulation of interleukin-12 production and biological process this GO :0045600 and positive regulation of fat cell differentiation and biological process this GO :0050848 and regulation of calcium-mediated signaling and biological process this GO :0070098 and chemokine-mediated signaling pathway and biological process, this GO :0004872 : receptor activity, this GO :0004872 : receptor activity and also this GO :0004930 : G-protein coupled receptor activity and also this GO :0004950 : chemokine receptor activity and also this GO :0005515 : protein binding, this GO :0004930 : G-protein coupled receptor activity, this GO :0004950 : chemokine receptor activity, this GO :0005515 : protein binding, chemokine-like receptor 1 |
| Identity: |
2121 |
| Gene: |
CMKLR1 |
More about : CMKLR1 |
| Long gene name: |
chemerin chemokine-like receptor 1 |
| Synonyms gene name: |
chemokine-like receptor 1 |
| Synonyms: |
RVER1 |
| Synonyms name: |
resolvin E1 receptor chemerin receptor |
| Locus: |
12q23, 3 |
| Discovery year: |
1995-11-22 |
| GenBank acession: |
U79526 |
| Entrez gene record: |
1240 |
| Classification: |
Chemerin receptor |
| Havana BLAST/BLAT: |
OTTHUMG00000169576 |