| Also known as: |
ESTROGEN RECEPTOR BETA 5 |
| Other names: |
Estrogen receptor beta, Nuclear receptor subfamily 3 group A member 2, estrogen nuclear receptor beta variant a, estrogen nuclear receptor beta variant b, estrogen receptor 2 (ER beta), estrogen receptor beta, estrogen receptor beta 4, nuclear receptor subfamily 3 group A member 2, estrogen receptor beta isoform 2 |
| Category: |
Antibodies |
| Subcategory: |
Mnoclonal antibodies |
| Gene name: |
ER-BETA, ER-beta, ESR-BETA, ESR2, ESRB, ESTRB, ESTRB, Erb, NR3A2, NR3A2, ESR2 |
| Gene name synonims: |
ER-BETA, ER-beta, ESR-BETA, ESR2, ESRB, ESTRB, ESTRB, Erb, NR3A2, NR3A2, ESR2 |
| Other gene names: |
ER-BETA, ER-beta, ESR-BETA, ESR2, ESRB, ESTRB, ESTRB, Erb, NR3A2, NR3A2, ESR2 |
| Clonality: |
Monoclonal |
| Immunoglobulin isotype: |
IgG1 |
| Clone: |
42149 |
| Host organism: |
Mouse (Mus musculus) |
| Species reactivity: |
Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby, Human (Homo sapiens) |
| Specificity and cross-reactivity: |
Although only the ERB1 variant appears fully functional, Approximately 75% to 80% of breast tumors have estrogen and/or progesterone receptors, Immunohistochemical studies have revealed a ubiquitous expression of ERB5 in normal colorectal tissue, Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, This particular antibody might cross react with speacies outside of the listed ones, a splice variant of the nuclear receptor hormone ERbeta (ESR2), and the presence of these receptors helps determine both the patient's prognosis and the effectiveness of hormonal therapy, and to be present in all primary colorectal carcinomas studied The detection of estrogen (ER) and progesterone (PR) receptors using immunohistochemical staining of formal fixed paraffin embedded (FFPE) tissue, has gradually replaced ligand binding assays (LBA), shown to exist in at least five isoforms (ERB1-ERB5), the remaining isoforms have been shown to form heterodimers with ERB1, thereby enhancing transcription, to become the most common method for the determination of the ER/PR status of breast tumors, ESTROGEN RECEPTOR BETA 5 Clone 5/25 specifically recognises human estrogen receptor beta 5 (ERB5) |
| Form/Appearance: |
Purified (Purified IgG - liquid) |
| Concentration: |
0mg/ml, IgG concentration 1 |
| Storage and shipping: |
If there is a precipitate in the vial we recommend you to briefly microcentrifugate it prior to use, Repeated freeze - thaw cycles may denature the peptide chains of the antibody and therefore should be maximally avoided, Shelf Life: 18 months from date of dispatch, the antibody should be stored undiluted, Storage in frost-free freezers is not recommended, Store the antibody at +4 degrees Celsius for short-term storage and at -20 degrees Celsius for long-term |
| Tested applications:: |
Immunohistology - Paraffin (IHC), Western Blot (WB) |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by MBS mono they should be stored frozen at - 24° |
| Gene target: |
ESTROGEN RECEPTOR BETA 5 |
| Short name: |
MOUSE Anti-HUMAN ESTROGEN RECEPTOR BETA 5 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
sapiens ESTROGEN RECEPTOR b 5 (Antibody to), MOUSE antibody to-H |
| Alternative technique: |
antibodies |