| Also known as: |
CD243 |
| Other names: |
ATP-binding cassette, ATP-binding cassette sub-family B member 1, Multidrug resistance protein 1, P-glycoprotein 1, P-glycoprotein 1, colchicin sensitivity, doxorubicin resistance, member 1, multidrug resistance protein 1, sub-family B (MDR/TAP), multidrug resistance protein 1 |
| Category: |
Antibodies |
| Subcategory: |
Mnoclonal antibodies |
| Gene name: |
CD243 |
| Other gene names: |
ABC20, ABCB1, CD243, CLCS, GP170, MDR1, MDR1, P-GP, PGY1, PGY1, ABCB1 |
| Clonality: |
Monoclonal |
| Immunoglobulin isotype: |
IgG2a |
| Clone: |
UIC2 |
| Host organism: |
Mouse (Mus musculus) |
| Species reactivity: |
Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby, Human (Homo sapiens) |
| Specificity and cross-reactivity: |
CD243 is expressed at low levels in the cell membrane of peripheral blood leucocytes, CD243 mediates resistance to many chemotherapeutic agents used for tumour suppression and is therefore of special interest to oncologists, Clone UIC2 can be used in a shift assay to selectively demonstrate the expression and functional activity of CD243 in a target cell Clone UIC2 does not cross-react with mitochondrial pyruvate carboxylase, Clone UIC2 is a strong inhibitor of CD243-mediated efflux and of the resistance of MDR cells to CD243 transported cytotoxic drugs, Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, This particular antibody might cross react with speacies outside of the listed ones, a transmembrane protein and member of the ABC transporter (ATP-binding cassette) family, also known as MDR1 (multi-drug resistance protein 1) and Pgp (P-glycoprotein), and constitutively expressed on the apical plasma membrane of excretory epithelial cells of the kidney, brain and small intestine, liver, which acts as an active efflux pump for a diverse range of lipophillic compounds, CD243 This item specifically recognises an extracellular conformational epitope of CD243 |
| Form/Appearance: |
Low Endotoxin (Purified IgG - liquid) |
| Concentration: |
0mg/ml, IgG concentration 1 |
| Storage and shipping: |
If there is a precipitate in the vial we recommend you to briefly microcentrifugate it prior to use, Repeated freeze - thaw cycles may denature the peptide chains of the antibody and therefore should be maximally avoided, Shelf Life: 18 months from date of dispatch, Storage in frost-free freezers is not recommended, only, the antibody should be stored undiluted, Store the antibody should be stored at -20 degrees Celsius |
| Tested applications:: |
Flow Cytometry (FACS), Functional Assay (FA), Immunofluorescence (IF), Immunohistology - Paraffin (IHC), Immunoprecipitation (IP), Immunohistology - Frozen (IHC) |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by MBS mono they should be stored frozen at - 24° |
| Gene target: |
CD243: Endotoxin |
| Short name: |
MOUSE Anti-HUMAN CD243:Low Endotoxin Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
sapiens CD243:Low Endotoxin (Antibody to), MOUSE antibody to-H |
| Alternative technique: |
antibodies |
| Identity: |
40 |
| Gene: |
ABCB1 |
More about : ABCB1 |
| Long gene name: |
ATP binding cassette subfamily B member 1 |
| Synonyms gene: |
PGY1 MDR1 CLCS |
| Synonyms gene name: |
colchicin sensitivity ATP-binding cassette, member 1 , sub-family B (MDR/TAP) |
| Synonyms: |
P-gp CD243 GP170 ABC20 |
| Synonyms name: |
multidrug resistance protein 1 |
| Locus: |
7q21, 12 |
| Discovery year: |
1986-01-01 |
| GenBank acession: |
M14758 |
| Entrez gene record: |
5243 |
| Pubmed identfication: |
3027054 |
| RefSeq identity: |
NM_000927 |
| Classification: |
CD molecules ATP binding cassette subfamily B |
| Havana BLAST/BLAT: |
OTTHUMG00000023393 |