| Also known as: |
PROGESTERONE RECEPTOR |
| Other names: |
Nuclear receptor subfamily 3 group C member 3, Progesterone receptor, nuclear receptor subfamily 3 group C member 3, progesterone receptor, progesterone receptor, progesterone receptor isoform B |
| Category: |
Antibodies |
| Subcategory: |
Mnoclonal antibodies |
| Gene name: |
NR3C3, NR3C3, PGR, PR, PR, PGR |
| Gene name synonims: |
NR3C3, NR3C3, PGR, PR, PR, PGR |
| Other gene names: |
NR3C3, NR3C3, PGR, PR, PR, PGR |
| Clonality: |
Monoclonal |
| Immunoglobulin isotype: |
IgG1 |
| Clone: |
1A6 |
| Host organism: |
Mouse (Mus musculus) |
| Species reactivity: |
Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby, Human (Homo sapiens) |
| Specificity and cross-reactivity: |
, Approximately 75% to 80% of breast tumors have estrogen and/or progesterone receptors, Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, The detection of estrogen (ER) and progesterone (PR) receptors using immunohistochemical staining of formal fixed paraffin embedded (FFPE) tissue, The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues, This particular antibody might cross react with speacies outside of the listed ones, and the presence of these receptors helps determine both the patient's prognosis and the effectiveness of hormonal therapy, has gradually replaced ligand binding assays (LBA), to become the most common method for the determination of the ER/PR status of breast tumors, PROGESTERONE RECEPTOR Clone 1A6 recognises the human progesterone receptor which is a member of the steroid family of nuclear receptors |
| Form/Appearance: |
S/N (Tissue Culture Supernatant - lyophilised) |
| Storage and shipping: |
Following reconstitution store the antibody should be stored at -20 degrees Celsius, If there is a precipitate in the vial we recommend you to briefly microcentrifugate it prior to use, Repeated freeze - thaw cycles may denature the peptide chains of the antibody and therefore should be maximally avoided, Shelf Life: 12 months from date of reconstitution, Storage in frost-free freezers is not recommended, Temperature variations in the range between +1C to +7C are tolerable, if preferred, the antibody should be stored undiluted, Prior to reconstitution Keep the antibody refrigerated at +4 degrees Celsius |
| Tested applications:: |
Immunohistology - Paraffin (IHC), Western Blot (WB) |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by MBS mono they should be stored frozen at - 24° |
| Gene target: |
PROGESTERONE RECEPTOR |
| Short name: |
MOUSE Anti-HUMAN PROGESTERONE RECEPTOR Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
sapiens PROGESTERONE RECEPTOR (Antibody to), MOUSE antibody to-H |
| Alternative technique: |
antibodies |
| Identity: |
8910 |
| Gene: |
PGR |
More about : PGR |
| Long gene name: |
progesterone receptor |
| Synonyms: |
PR NR3C3 |
| Locus: |
11q22, 1 |
| Discovery year: |
2001-06-22 |
| GenBank acession: |
M15716 |
| Entrez gene record: |
5241 |
| Classification: |
Nuclear hormone receptors |
| Havana BLAST/BLAT: |
OTTHUMG00000167531 |