| Also known as: |
CD230 |
| Other names: |
Gerstmann-Strausler-Scheinker syndrome, Major prion protein, N/A, N/A, fatal familial insomnia), major prion protein, prion protein (p27-30) (Creutzfeldt-Jakob disease, major prion protein |
| Category: |
Antibodies |
| Subcategory: |
Mnoclonal antibodies |
| Gene name: |
CD230 |
| Other gene names: |
PRNP, PRP, PRPC, PrP, Prp, SIP, SIP, PRNP |
| Clonality: |
Monoclonal |
| Immunoglobulin isotype: |
IgG1 |
| Clone: |
5121 |
| Host organism: |
Mouse (Mus musculus) |
| Species reactivity: |
Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby, Sheep |
| Specificity and cross-reactivity: |
After denaturation/protease treatment this antibody recognises only the disease-associated form (PrP<, CD230, Clinically, Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, The major pathological changes seen are neuronal loss, These diseases are biologically unique, This item will recognise PrP<, This particular antibody might cross react with speacies outside of the listed ones, a normal cellular form (PrP<, also known as the prion protein (PrP) exists in two alternate forms, and PrP<, as they are believed by some to be transmitted by an infectious agent comprised only of protein, astrocytic proliferation and accumulation of the prion protein PrP<, proliferation and branching of glial cells, these diseases present with motor disturbances and behavioural changes, vacuolation (spongiform change), which can form amyloid plaques, with no nucleic acid component, ), ), ) and a disease-associated form (PrP<, /sup>, /sup>, /sup>, /sup>, /sup>, /sup>, CD230 Transmissible spongiform encephalopathies (TSEs) or prion diseases are fatal infectious neurodegenerative diseases of humans and animals, Sc<, Sc<, Sc<, Sc<, The normal and pathological forms of the prion protein have identical amino acid sequences and differ only in their folded tertiary structure and biochemical properties, _x000D__x000D_, c<, c<, sup>, sup>, sup>, sup>, sup>, sup> |
| Form/Appearance: |
Purified (Purified IgG - liquid) |
| Concentration: |
1 miligram per 1 mililiter, IgG concentration 0 |
| Storage and shipping: |
If there is a precipitate in the vial we recommend you to briefly microcentrifugate it prior to use, Repeated freeze - thaw cycles may denature the peptide chains of the antibody and therefore should be maximally avoided, Shelf Life: 18 months from date of dispatch, the antibody should be stored undiluted, Storage in frost-free freezers is not recommended, Store the antibody at +4 degrees Celsius for short-term storage and at -20 degrees Celsius for long-term |
| Tested applications:: |
ELISA (EIA), Immunohistology - Paraffin (IHC), Western Blot (WB) |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by MBS mono they should be stored frozen at - 24° |
| Gene target: |
CD230 |
| Short name: |
MOUSE Anti-SHEEP CD230 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
MOUSE antibody to-ovine CD230 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
9449 |
| Gene: |
PRNP |
More about : PRNP |
| Long gene name: |
prion protein |
| Synonyms gene: |
PRIP GSS CJD |
| Synonyms gene name: |
prion protein (p27-30) |
| Synonyms: |
CD230 PRP AltPrP |
| Synonyms name: |
Creutzfeldt-Jakob disease Gerstmann-Strausler-Scheinker syndrome fatal familial insomnia p27-30 |
| Locus: |
20p13 |
| Discovery year: |
1986-01-01 |
| GenBank acession: |
M13899 |
| Entrez gene record: |
5621 |
| RefSeq identity: |
NM_000311 |
| Classification: |
CD molecules |
| Havana BLAST/BLAT: |
OTTHUMG00000031786 |
| Locus Specific Databases: |
Prion Protein/CJD database |