| Also known as: |
CD314 |
| Other names: |
Killer cell lectin-like receptor subfamily K member 1, N/A, NK cell receptor D, NK cell receptor D, NKG2-D type II integral membrane protein, NKG2-D type II integral membrane protein, NKG2-D-activating NK receptor, NKG2-D-activating NK receptor, killer cell lectin-like receptor subfamily K member 1, NKG2-D type II integral membrane protein |
| Category: |
Antibodies |
| Subcategory: |
Mnoclonal antibodies |
| Gene name: |
CD314 |
| Other gene names: |
D12S2489E, KLRK1, N/A, NKG2D, KLRC4-KLRK1 |
| Clonality: |
Monoclonal |
| Immunoglobulin isotype: |
IgG1 |
| Clone: |
1D11 |
| Host organism: |
Mouse (Mus musculus) |
| Species reactivity: |
Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby, Human (Homo sapiens) |
| Specificity and cross-reactivity: |
CD314 forms homodimers that signal through an associated DAP10 adaptor protein, CD8 T cells and gamma delta T cells, Ligand binding toCD314 results in NK cell activation and potent costimulation of effector T cells, MICB and UL16 binding protein (ULBP), Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, This particular antibody might cross react with speacies outside of the listed ones, _x000D__x000D_CD314 is a C-type lectin-like activating receptor which is expressed on most natural killer (NK) cells, _x000D__x000D_Clone 1D11 is reported to inhibit T cell recognition of MICA (1, _x000D__x000D_Ligands of CD314 include MICA, also known as natural killer receptor G2 (NKG2D) and as killer cell lectin-like receptor subfamily K, member 1 (KLRK1), which are inducibly expressed, 6), CD314 This item is specific for CD314 |
| Form/Appearance: |
Purified (Purified IgG - liquid) |
| Concentration: |
0 mg/ml, IgG concentration 1 |
| Storage and shipping: |
If there is a precipitate in the vial we recommend you to briefly microcentrifugate it prior to use, Repeated freeze - thaw cycles may denature the peptide chains of the antibody and therefore should be maximally avoided, Shelf Life: 18 months from date of dispatch, Storage in frost-free freezers is not recommended, Store the antibody at +4 degrees Celsius for short-term storage and at -20 degrees Celsius for long-term |
| Tested applications:: |
Flow Cytometry (FACS), Immunohistology - Frozen (IHC), Immunoprecipitation (IP) |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by MBS mono they should be stored frozen at - 24° |
| Gene target: |
CD314 |
| Short name: |
MOUSE Anti-HUMAN CD314 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
sapiens CD314 (Antibody to), MOUSE antibody to-H |
| Alternative technique: |
antibodies |
| Identity: |
18788 |
| Gene: |
KLRK1 |
More about : KLRK1 |
| Long gene name: |
killer cell lectin like receptor K1 |
| Synonyms gene: |
D12S2489E |
| Synonyms gene name: |
DNA segment on chromosome 12 (unique) 2489 expressed sequence killer cell lectin-like receptor subfamily K, member 1 |
| Synonyms: |
NKG2D KLR NKG2-D CD314 |
| Locus: |
12p13, 2 |
| Discovery year: |
2003-12-12 |
| GenBank acession: |
AJ001687 |
| Entrez gene record: |
22914 |
| Pubmed identfication: |
9683661 2007850 |
| RefSeq identity: |
NM_007360 |
| Classification: |
Killer cell lectin like receptors CD molecules C-type lectin domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000168574 |