| known also as: |
Anti-RABBIT ANTI VISA |
| known also as: |
RABBIT ANTI VISA |
| known also as: |
Lapin ANTI VISA |
| known also as: |
VISA |
| Other names: |
CARD adapter inducing interferon beta, CARD adapter inducing interferon beta, CARD adaptor inducing IFN-beta, Cardif, IFN-B promoter stimulator 1, IPS-1, Interferon beta promoter stimulator protein 1, Mitochondrial antiviral-signaling protein, Putative NF-kappa-B-activating protein 031N, Virus-induced-signaling adapter, interferon beta promoter stimulator protein 1, mitochondrial antiviral signaling protein, mitochondrial antiviral-signaling protein, putative NF-kappa-B-activating protein 031N, virus-induced signaling adaptor, virus-induced-signaling adapter, mitochondrial antiviral-signaling protein isoform 2 |
| Gene name: |
VISA |
| Other gene names: |
CARDIF, Cardif, IPS-1, IPS-1, IPS1, IPS1, KIAA1271, MAVS, MAVS, VISA, VISA, VISA, MAVS |
| Category: |
Antibodies |
| Clonality: |
Polyclonal |
| Immunoglobulin isotype: |
Polyclonal IgG |
| Clone: |
Polyclonal antibody |
| Host organism: |
Rabbit |
| Species reactivity: |
Human |
| Specificity and cross-reactivity: |
IRF3 and IRF7, Multiple isoforms of VISA have been identified, VISA is believed to activate the same pathways following detection of extracellular dsRNA by TLR3 and it has been hypothosized that VISA may protect cells from apoptosis, _x000D__x000D_VISA acts downstream of DDX58 and IFIH1/MDA5, _x000D__x000D_VISA is a ubiquitously expressed protein present in a range of cell types including T-cells, _x000D__x000D_VISA is an important protein required for innate immune defence against viruses, a protein of approximately 56, also known as MAVS and KIAA1271, and to the subsequent induction of antiviral cytokines such as IFN-beta and RANTES (CCL5), highest levels in tissues of the heart, liver, monocytes and epithelial cells, placenta and in peripheral blood leukocytes, skeletal muscle, to coordinate pathways leading to the activation of NF-kappa-B, which detect intracellular dsRNA produced during viral replication, 5kDa located on the mitochondrial membrane, VISA This item recognises the Human Virus-induced-signalling-adaptor (VISA) |
| Form/Appearance: |
Purified (Purified IgG - liquid) |
| Concentration: |
0mg/ml, IgG concentration 1 |
| Storage and shipping: |
Avoid repeated freezing and thawing as this may denature the antibody, Shelf Life: 18 months from date of dispatch, Should productone contain a precipitate we recommend microcentrifugation before use, Storage in frost-free freezers is not recommended, if preferred, or productone should be stored at -20 degrees Celsius, productone should be stored undiluted, Store at +Store productone at +4 degrees Celsius |
| Tested for:: |
Western Blot (WB), Immunohistology - Paraffin (IHC) |
| Description: |
Polyclonal antibodies generally are more stable and retain their reactivity under unfavorable conditions, Polyclonal antibodies have series of advantages - larger batches can be supplied at a time, Properly used, To obtain more detailed information on productone, please, refer to the full product datasheet, the time needed for production is considerably shorter, they are inexpensive to manufacture and respectively to buy, this antibody will ensure excellent and reproducible results with guaranteed success for the applications that it is tested in, productone is a polyclonal antibody of high purity and binding affinity for the antigen that it is risen against |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, avoid cycles of freezing and thawing, please, In order to retain the quality and the affinity of productone unchanged |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by MBS Polyclonals_1 they should be stored frozen at - 24° |
| Gene target: |
VISA |
| Short name: |
Anti-VISA Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
antibody to-VISA (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
29233 |
| Gene: |
MAVS |
More about : MAVS |
| Long gene name: |
mitochondrial antiviral signaling protein |
| Synonyms: |
VISA KIAA1271 IPS-1 Cardif |
| Synonyms name: |
virus-induced signaling adaptor IFN-B promoter stimulator 1 CARD adaptor inducing IFN-beta |
| Locus: |
20p13 |
| Discovery year: |
2009-04-01 |
| GenBank acession: |
DQ174270 |
| Entrez gene record: |
57506 |
| Pubmed identfication: |
16125763 16153868 |
| RefSeq identity: |
NM_020746 |
| Classification: |
Caspase recruitment domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000031765 |