| known also as: |
Anti-RABBIT ANTI RAT ALPHA SYNUCLEIN (pSer129) |
| known also as: |
RABBIT ANTI RAT ALPHA SYNUCLEIN (pSer129) |
| known also as: |
Lapin ANTI Rattus norvegicus ALPHA SYNUCLEIN (pSer129) |
| known also as: |
ALPHA SYNUCLEIN |
| Other names: |
Alpha-synuclein, N/A, alpha (non A4 component of amyloid precursor), alpha-synuclein, synuclein, alpha-synuclein |
| Other gene names: |
N/A, N/A, Snca, Snca |
| Category: |
Antibodies |
| Clonality: |
Polyclonal |
| Immunoglobulin isotype: |
Polyclonal IgG |
| Clone: |
Polyclonal antibody |
| Host organism: |
Rabbit |
| Species reactivity: |
Rat |
| Specificity and cross-reactivity: |
15kDa protein seen predominantly in the neocortex, Alpha synuclein has several possible phosphorylation sites, Alpha synuclein is a 140 amino acid, Alpha synuclein is normally a soluble, Its normal cellular function has not been definitively determined, Lewy bodies are a hallmark pathological feature of Parkinson's disease and other neurodegenerative diseases, Ser129 in particular can be phosphorylated by G-protein-coupled receptor kinases, Studies suggest that this phosphorylation promotes formation of alpha synuclein filaments, but it can aggregate at high concentrations to form insoluble fibrils which, but it is thought to be involved in the regulation of neuronal plasticity, dopamine neurotransmission and other membrane-associated processes at the presynaptic terminal, form Lewy bodies, hippocampus, in association with other proteins such as ubiquitin, neurofilament protein and alpha B crystalline, substantia nigra, thalamus and cerebellum, unfolded protein, with hyperphosphorylation of Ser129 seen in Lewy bodies, ALPHA SYNUCLEIN This item specifically recognises rat alpha synuclein when phosphorylated at Ser129 |
| Form/Appearance: |
Purified (Purified IgG - liquid) |
| Storage and shipping: |
Avoid repeated freezing and thawing as this may denature the antibody, Shelf Life: 18 months from date of dispatch, Should productone contain a precipitate we recommend microcentrifugation before use, Storage in frost-free freezers is not recommended, if preferred, or productone should be stored at -20 degrees Celsius, productone should be stored undiluted, Store at +Store productone at +4 degrees Celsius |
| Tested for:: |
Western Blot (WB) |
| Description: |
Polyclonal antibodies generally are more stable and retain their reactivity under unfavorable conditions, Polyclonal antibodies have series of advantages - larger batches can be supplied at a time, Properly used, To obtain more detailed information on productone, please, refer to the full product datasheet, the time needed for production is considerably shorter, they are inexpensive to manufacture and respectively to buy, this antibody will ensure excellent and reproducible results with guaranteed success for the applications that it is tested in, productone is a polyclonal antibody of high purity and binding affinity for the antigen that it is risen against |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, avoid cycles of freezing and thawing, please, In order to retain the quality and the affinity of productone unchanged |
| Gene target: |
ALPHA SYNUCLEIN (pSer129) |
| Short name: |
Anti-RAT ALPHA SYNUCLEIN (pSer129) |
| Alternative name: |
antibody to-RAT a SYNUCLEIN (pSer129) |