| known also as: |
Anti-RABBIT ANTI 14-3-3 SIGMA |
| known also as: |
RABBIT ANTI 14-3-3 SIGMA |
| known also as: |
Lapin ANTI 14-3-3 SIGMA |
| known also as: |
14-3-3 SIGMA |
| Other names: |
14-3-3 protein sigma, 14-3-3 protein sigma, N/A, Stratifin, 14-3-3 protein sigma |
| Gene name: |
14-3-3 SIGMA |
| Other gene names: |
N/A, N/A, SFN, SFN |
| Category: |
Antibodies |
| Clonality: |
Polyclonal |
| Immunoglobulin isotype: |
Polyclonal IgG |
| Clone: |
Polyclonal antibody |
| Host organism: |
Rabbit |
| Species reactivity: |
Sheep |
| Specificity and cross-reactivity: |
14-3-3 also negatively regulates both the glucocorticoid receptor and the activity of PKB/Akt which stabilizes p27 Kip1, 14-3-3 sigma targets, DeltaNp63alpha for proteasome degradation, In reaction to DNA damage and along with RACK1, It is a member of the 14-3-3 family which consists of 30 kDa proteins that are involved in multiple protein kinase signalling pathways, Mitosis is regulated by 14-3-3 sigma through binding keratin filaments and sequestering cyclin B1 and cdc2, Protein interactions with 14-3-3 show distinct preference for its different isotypes and are regulated by phosphorylation of both 14-3-3 and the bound protein, Sequestration of Bax by 14-3-3 sigma inhibits apoptosis whereas sequestration of 14-3-3 sigma by CARP-1 induces it, _x000D__x000D_14-3-3 sigma binds c-fos activating the MAPK pathway, _x000D__x000D_14-3-3 sigma is expressed mostly in epithelial cells and has been associated with cancers including breast, _x000D__x000D_This item may not react with recombinant proteins that are not N-acetylated, adenoid cystic, and papillary, colorectal, cytoskeletal structure, endometrial adenocarcinoma, epithelial ovarian, intracellular trafficking and targeting, nasopharyngeal, p73-dependent induction of 14-3-3 sigma regulates chemo sensitivity in breast cancers with p53 mutations, prostate, regulation of cell cycle progression, transcription, 14-3-3 SIGMA This item recognises 14-3-3 sigma in all mammals |
| Form/Appearance: |
Serum (Serum - liquid) |
| Storage and shipping: |
Avoid repeated freezing and thawing as this may denature the antibody, Shelf Life: 18 months from date of dispatch, Should productone contain a precipitate we recommend microcentrifugation before use, Storage in frost-free freezers is not recommended, if preferred, or productone should be stored at -20 degrees Celsius, productone should be stored undiluted, Store at +Store productone at +4 degrees Celsius |
| Tested for:: |
Western Blot (WB) |
| Description: |
Polyclonal antibodies generally are more stable and retain their reactivity under unfavorable conditions, Polyclonal antibodies have series of advantages - larger batches can be supplied at a time, Properly used, To obtain more detailed information on productone, please, refer to the full product datasheet, the time needed for production is considerably shorter, they are inexpensive to manufacture and respectively to buy, this antibody will ensure excellent and reproducible results with guaranteed success for the applications that it is tested in, productone is a polyclonal antibody of high purity and binding affinity for the antigen that it is risen against |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, avoid cycles of freezing and thawing, please, In order to retain the quality and the affinity of productone unchanged |
| Gene target: |
14-3-3 SIGMA |
| Short name: |
Anti-14-3-3 SIGMA |
| Alternative name: |
antibody to-14-3-3 SIGMA |
| Identity: |
12854 |
| Gene: |
YWHAQ |
More about : YWHAQ |
| Long gene name: |
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta |
| Synonyms gene name: |
theta , theta polypeptide protein, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein |
| Synonyms: |
HS1 14-3-3 |
| Synonyms name: |
protein tau |
| Locus: |
2p25, 1 |
| Discovery year: |
1999-08-20 |
| GenBank acession: |
AF070556 |
| Entrez gene record: |
10971 |
| Pubmed identfication: |
11080204 |
| RefSeq identity: |
NM_006826 |
| Classification: |
14-3-3 phospho-serine/phospho-threonine binding proteins |
| Havana BLAST/BLAT: |
OTTHUMG00000013848 |