| known also as: |
Anti-RABBIT ANTI DARPP-32 (N-TERMINAL) |
| known also as: |
RABBIT ANTI DARPP-32 (N-TERMINAL) |
| known also as: |
Lapin ANTI DARPP-32 (N-TERMINAL) |
| known also as: |
DARPP-32 |
| Other names: |
DARPP-32, Dopamine- and cAMP-regulated neuronal phosphoprotein, Protein phosphatase 1 regulatory subunit 1B, dopamine- and cAMP-regulated neuronal phosphoprotein, dopamine- and cAMP-regulated phosphoprotein DARPP-32, neuronal phosphoprotein DARPP-32, protein phosphatase 1, protein phosphatase 1 regulatory subunit 1B, regulatory (inhibitor) subunit 1B, protein phosphatase 1 regulatory subunit 1B |
| Gene name: |
DARPP-32 |
| Other gene names: |
Darpp-32, Darpp32, N/A, Ppp1r1b, Ppp1r1b |
| Category: |
Antibodies |
| Clonality: |
Polyclonal |
| Immunoglobulin isotype: |
Polyclonal IgG |
| Clone: |
Polyclonal antibody |
| Host organism: |
Rabbit |
| Species reactivity: |
Rat |
| Specificity and cross-reactivity: |
Conversely when phosphorylated at threonine-75 by CDK5, DARPP-32 becomes an inhibitor of protein kinase A, DARPP-32 has been linked to gastric cancer, DARPP-32 is converted into an inhibitor of protein phosphatase-1 when it is phosphorylated by protein kinase A as a result of dopaminergic receptor stimulation, However this phosphorylation is reversed on stimulation of N-methyl-D-aspartate (NMDA) receptors by glutamate, The phosphatase is highly expressed in the nucleus accumbens, being expressed at lower levels in the neocortical regions, caudate nucleus, cerebellar cortex and putamen, DARPP-32 This item recognises DARPP-32 a 32 kDa protein phosphatase which modulates cell signalling in neurons |
| Form/Appearance: |
Purified (Purified IgG - liquid) |
| Storage and shipping: |
Avoid repeated freezing and thawing as this may denature the antibody, Shelf Life: 12 months from date of dispatch, Should productone contain a precipitate we recommend microcentrifugation before use, Storage in frost-free freezers is not recommended, if preferred, or productone should be stored at -20 degrees Celsius, productone should be stored undiluted, Store at +Store productone at +4 degrees Celsius |
| Tested for:: |
Western Blot (WB) |
| Description: |
Polyclonal antibodies generally are more stable and retain their reactivity under unfavorable conditions, Polyclonal antibodies have series of advantages - larger batches can be supplied at a time, Properly used, To obtain more detailed information on productone, please, refer to the full product datasheet, the time needed for production is considerably shorter, they are inexpensive to manufacture and respectively to buy, this antibody will ensure excellent and reproducible results with guaranteed success for the applications that it is tested in, productone is a polyclonal antibody of high purity and binding affinity for the antigen that it is risen against |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, avoid cycles of freezing and thawing, please, In order to retain the quality and the affinity of productone unchanged |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by MBS Polyclonals_1 they should be stored frozen at - 24° |
| Gene target: |
DARPP-32 |
| Short name: |
Anti-DARPP-32 (N-TERMINAL) Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
antibody to-DARPP-32 (N-TERMINAL) (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
9287 |
| Gene: |
PPP1R1B |
More about : PPP1R1B |
| Long gene name: |
protein phosphatase 1 regulatory inhibitor subunit 1B |
| Synonyms gene name: |
protein phosphatase 1, regulatory (inhibitor) subunit 1B |
| Synonyms: |
DARPP-32 FLJ20940 |
| Synonyms name: |
dopamine and cAMP regulated phosphoprotein |
| Locus: |
17q12 |
| Discovery year: |
1993-01-22 |
| GenBank acession: |
AI124650 |
| Entrez gene record: |
84152 |
| Pubmed identfication: |
8120638 |
| RefSeq identity: |
NM_032192 |
| Classification: |
Protein phosphatase 1 regulatory subunits |
| Havana BLAST/BLAT: |
OTTHUMG00000133210 |