| known also as: |
Anti-GOAT ANTI HUMAN CD156b (C-TERMINAL) |
| known also as: |
Caprine ANTI HUMAN CD156b (C-TERMINAL) |
| known also as: |
Caprinae ANTI Homo sapiens CD156b (C-TERMINAL) |
| known also as: |
CD156b |
| Other names: |
ADAM metallopeptidase domain 17, ADAM metallopeptidase domain 18, Disintegrin and metalloproteinase domain-containing protein 17, Snake venom-like protease, TNF-alpha convertase, TNF-alpha convertase, TNF-alpha converting enzyme, TNF-alpha-converting enzyme, alpha, converting enzyme, disintegrin and metalloproteinase domain-containing protein 17, snake venom-like protease, tumor necrosis factor, disintegrin and metalloproteinase domain-containing protein 17 preproprotein |
| Gene name: |
CD156b |
| Other gene names: |
ADAM 17, ADAM17, ADAM18, CD156B, CSVP, CSVP, NISBD, TACE, TACE, ADAM17 |
| Category: |
Antibodies |
| Clonality: |
Polyclonal |
| Immunoglobulin isotype: |
Polyclonal IgG |
| Clone: |
Polyclonal antibody |
| Host organism: |
Goat |
| Species reactivity: |
Human |
| Specificity and cross-reactivity: |
CD156b also causes a number of inflammatory modulators to undergo ectodomain shedding, CD156b is 125kD, CD156b is therefore a prospective therapeutic target in human cancer, CD156b plays a prominent role in the activation of the Notch signalling pathway, IL-1RII, L-selectin, TNFR55, _x000D_ADAM17 plays a pivotal role in several acquired tumor cell capabilities by mediating the availability of soluble transforming growth factor-alpha, a type I transmembrane glycoprotein which belongs to the ADAM (a disintegrin and metalloprotease domain) family, and establishing an autocrine signaling pathway through endogenous EGFR activation, and functions as a tumour necrosis factor-alpha converting enzyme (TACE), and the amyloid precursor protein among others, including TNFR75, CD156b This item detects an epitope within the C-terminus of isoform 1 of CD156b |
| Form/Appearance: |
Purified (Purified IgG - liquid) |
| Storage and shipping: |
Avoid repeated freezing and thawing as this may denature the antibody, Shelf Life: 18 months from date of dispatch, Should productone contain a precipitate we recommend microcentrifugation before use, Storage in frost-free freezers is not recommended, if preferred, or productone should be stored at -20 degrees Celsius, productone should be stored undiluted, Store at +Store productone at +4 degrees Celsius |
| Tested for:: |
ELISA (EIA), Western Blot (WB) |
| Description: |
Polyclonal antibodies generally are more stable and retain their reactivity under unfavorable conditions, Polyclonal antibodies have series of advantages - larger batches can be supplied at a time, Properly used, To obtain more detailed information on productone, please, refer to the full product datasheet, the time needed for production is considerably shorter, they are inexpensive to manufacture and respectively to buy, this antibody will ensure excellent and reproducible results with guaranteed success for the applications that it is tested in, productone is a polyclonal antibody of high purity and binding affinity for the antigen that it is risen against |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, avoid cycles of freezing and thawing, please, In order to retain the quality and the affinity of productone unchanged |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by MBS Polyclonals_1 they should be stored frozen at - 24° |
| Gene target: |
CD156b |
| Short name: |
GOAT ANTI HUMAN CD156b (C-TERMINAL) Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
sapiens CD156b (C-TERMINAL) (Antibody to), caprine antibody to H |
| Alternative technique: |
antibodies |
| Identity: |
11525 |
| Gene: |
TACE |
More about : TACE |
| Long gene name: |
ADAM metallopeptidase domain 17 |
| Synonyms gene name: |
alpha, converting enzyme , tumor necrosis factor |
| Synonyms: |
cSVP CD156B ADAM17 |
| Locus: |
2p25, 1 |
| Discovery year: |
1997-04-10 |
| GenBank acession: |
U69611 |
| Entrez gene record: |
6868 |
| Pubmed identfication: |
9034190 9574564 |
| Classification: |
ADAM metallopeptidase domain containing CD molecules |
| Havana BLAST/BLAT: |
OTTHUMG00000090425 |