| Long name: |
HAO1 Primary Polyclonal Antibody |
| Also known as: |
HAO1 PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
HAO1 |
| Specificity: |
This is a highly specific antibody against HAO1 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human GOX/HAO1 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
2-hydroxyacid oxidases, HAO1 is also able to convert glyoxylate to oxalate, HAO1 is localized to peroxisomes and aids in organic acid metabolism via 2-hydroxyacid oxidase activity, HAO1 is thought to play a role in the pathophysiology of hyperoxaluria type 1, HAO1 prefenentially oxidizes the substrate glycolate and also oxidizes other substrates, Hyperoxaluria type 1 is characterized by an accumulation of oxalate that is thought to lead to precipitates of calcium oxalate in kidneys which can be fatal, The oxidation of glycolate yields glyoxylate which is utilized for peroxisomal synthesis of glycine, a peroxisomal enzyme, are enzymes that require a flavin cofactor to oxidize 2-hydroxyacids to 2-ketoacids while reducing oxygen to hydrogen peroxide, including 2-hydroxy fatty acids as well as L-?hydroxy acids of moderately short chain lengths, leading to accumulation of glyoxylate, such as HAO1, which is caused by defects in AGXT, GOX is a 370 amino acid protein that is expressed in liver and pancreas |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
GOX, GOX1, HAO1, HAOX1, HAOX1_HUMAN, Hydroxyacid oxidase 1, MGC142225, MGC142227, OTTHUMP00000030231, S 2 hydroxy acid oxidase, Glycolate oxidase |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
HAO1 |
| Short name: |
HAO1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
HAO1 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
4809 |
| Gene: |
HAO1 |
More about : HAO1 |
| Long gene name: |
hydroxyacid oxidase 1 |
| Synonyms gene: |
GOX1 |
| Synonyms gene name: |
hydroxyacid oxidase (glycolate oxidase) 1 |
| Synonyms: |
GOX |
| Synonyms name: |
glycolate oxidase 1 |
| Locus: |
20p12, 3 |
| Discovery year: |
1999-09-09 |
| GenBank acession: |
AL021879 |
| Entrez gene record: |
54363 |
| Pubmed identfication: |
9891009 |
| Havana BLAST/BLAT: |
OTTHUMG00000031841 |