| Long name: |
Fbxw7 Primary Polyclonal Antibody |
| Also known as: |
Fbxw7 PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
Fbxw7 |
| Specificity: |
This is a highly specific antibody against Fbxw7 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
519-549/707 |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Fbxw7/hCDC4 |
| Gene ID number: |
55294 |
| Swiss Prot: |
Q969H0 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Acts as a negative regulator of JNK signaling by binding to phosphorylated JUN and promoting its ubiquitination and subsequent degradation (PubMed:14739463), Identified substrates include cyclin-E (CCNE1 or CCNE2), JUN, MYC, NOTCH1 released notch intracellular domain (NICD), PubMed:11585921, PubMed:12354302, PubMed:14739463, PubMed:15103331, PubMed:17558397, PubMed:17873522, PubMed:22608923), Recognizes and binds phosphorylated sites/phosphodegrons within target proteins and thereafter bring them to the SCF complex for ubiquitination (PubMed:17434132), and probably PSEN1 (PubMed:11565034, Substrate recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
Archipelago homolog, CDC4, F-box and WD-40 domain-containing protein 7, F-box protein FBX30, F-box/WD repeat-containing protein 7, FBW6, FBW7, FBX30, FBXO30, FBXW6, FBXW7, SEL-10, SEL10, hAgo, hCdc4, AGO |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
Fbxw7 |
| Short name: |
Fbxw7 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
Fbxw7 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
52397 |
| Gene: |
FBXW7-AS1 |
More about : FBXW7-AS1 |
| Long gene name: |
FBXW7 antisense RNA 1 |
| Synonyms: |
DEAR DEspR |
| Synonyms name: |
dual-endothelin1/VEGFsp receptor dual endothelin-1(VEGFsp)/angiotensin II receptor |
| Locus: |
4q31, 3 |
| Discovery year: |
2016-10-13 |
| Entrez gene record: |
102191832 |