| Long name: |
SUPT16H Primary Polyclonal Antibody |
| Also known as: |
SUPT16H PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
SUPT16H |
| Specificity: |
This is a highly specific antibody against SUPT16H |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human SUPT16H/CDC68 |
| Gene ID number: |
11198 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, DNA replication and DNA repair, During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure, It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II), a chromatin-remodeling complex recruited by vitamin D receptor (VDR), a general chromatin factor that acts to reorganize nucleosomes, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II, which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene, Component of the FACT complex |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
Chromatin specic transcription elongation factor 140 kDa subunit, Chromatin-specic transcription elongation factor 140 kDa subunit, FACT, FACT 140 kDa subunit, FACT complex subunit SPT16, FACTP140, FLJ10857, FLJ14010, Facilitates chromatin transcription complex subunit SPT16, SP16H_HUMAN, Suppressor of Ty 16 homolog, Supt16h, hSPT16, CDC68 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
SUPT16H |
| Short name: |
SUPT16H Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
SUPT16H (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
11465 |
| Gene: |
SUPT16H |
More about : SUPT16H |
| Long gene name: |
SPT16 homolog, facilitates chromatin remodeling subunit |
| Synonyms gene name: |
cerevisiae) , suppressor of Ty (S, cerevisiae) 16 homolog suppressor of Ty 16 homolog (S |
| Synonyms: |
FACT FACTP140 SPT16/CDC68 FLJ14010 FLJ10857 CDC68 |
| Synonyms name: |
facilitates chromatin remodeling 140 kDa subunit |
| Locus: |
14q11, 2 |
| Discovery year: |
1996-08-21 |
| GenBank acession: |
AF152961 |
| Entrez gene record: |
11198 |
| Pubmed identfication: |
9489704 11239457 |
| RefSeq identity: |
NM_007192 |
| Havana BLAST/BLAT: |
OTTHUMG00000029685 |