| Long name: |
DR6 Primary Polyclonal Antibody |
| Also known as: |
DR6 PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
DR6 |
| Specificity: |
This is a highly specific antibody against DR6 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
140-170/655 |
| Subcellular location: |
Extracellular |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human DR6 |
| Gene ID number: |
27242 |
| Swiss Prot: |
O75509 |
| Tested Applications: |
FCM |
| Recommended dilutions: |
FCM(1:20-100) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Can also promote apoptosis mediated by BAX and by the release of cytochrome c from the mitochondria into the cytoplasm, IL10, IL13 and IFNG by Th2 cells, IL5, IgM and IgM in response to antigens, May inhibit the activation of JNK in response to T-cell stimulation, N-APP binds TNFRSF21, Negatively regulates T-cell responses and the release of cytokines such as IL4, Negatively regulates oligodendrocyte survival, Negatively regulates the production of IgG, Plays a role in neuronal apoptosis, Plays a role in signaling cascades triggered by stimulation of T-cell receptors, Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP), and is required for both normal cell body death and axonal pruning, in the adaptive immune response and in the regulation of T-cell differentiation and proliferation, including apoptosis in response to amyloid peptides derived from APP, maturation and myelination, possibly via a pathway that involves the activation of NF-kappa-B, this triggers caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6), Promotes apoptosis |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
BM-018, CD358, Death receptor 6, TNFRSF21, Tumor necrosis factor receptor superfamily member 21, UNQ437/PRO868, DR6 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
DR6 |
| Short name: |
DR6 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
DR6 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
13469 |
| Gene: |
TNFRSF21 |
More about : TNFRSF21 |
| Long gene name: |
TNF receptor superfamily member 21 |
| Synonyms gene name: |
member 21 , tumor necrosis factor receptor superfamily |
| Synonyms: |
DR6 CD358 |
| Synonyms name: |
death receptor 6 |
| Locus: |
6p12, 3 |
| Discovery year: |
2001-07-27 |
| GenBank acession: |
AF068868 |
| Entrez gene record: |
27242 |
| Pubmed identfication: |
9714541 |
| RefSeq identity: |
NM_014452 |
| Classification: |
CD molecules Tumor necrosis factor receptor superfamily |
| Havana BLAST/BLAT: |
OTTHUMG00000014796 |