| Long name: |
Perforin Primary Polyclonal Antibody |
| Also known as: |
Perforin PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
Perforin |
| Specificity: |
This is a highly specific antibody against Perforin |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Perforin |
| Gene ID number: |
5551 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
CTL granules containing perforin are exocytosed, During CTL-mediated cytotoxicity, IL-3, IL-4, IL-6 and to a lesser degree, It has been shown that abrogation of perforin function by Ca2+-complexing agents leads to decreased levels of necrosis, Perforin activity has been shown to be induced by IL-2, Perforin is a pore-forming protein that facilitates the entry of cytotoxic serine proteases, Perforin is primarily expressed in cytotoxic T lymphocytes (CTL) and natural killer (NK) cells, TNF and IFN-Î, but has also been observed in an astrocyte population of the human brain, demonstrating that both necrosis and apoptosis contribute to CTL-mediated cytotoxicity, into target cells by forming transmembrane channels in target cell membranes, such as granzymes, which also plays a role in autoimmune diseases and transplant rejection, ³, The major defense of the body against virus-infected and tumorigenic cells is cytotoxic T lymphocyte (CTL)-mediated cytotoxicity |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
FLH2, HPLH2, Lymphocyte pore forming protein, Lymphocyte pore-forming protein, MGC65093, P1, PERF_HUMAN, PFP, PGFL, PIGF, PIGF-2, PLGF, PRF 1, PRF1, Perforin 1, Perforin 1 precursor, Perforin 1 preforming protein, Perforin-1, Pore forming protein, SHGC-10760, Cytolysin |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
Perforin |
| Short name: |
Perforin Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
Perforin (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
9360 |
| Gene: |
PRF1 |
More about : PRF1 |
| Long gene name: |
perforin 1 |
| Synonyms gene name: |
perforin 1 (pore forming protein) |
| Synonyms: |
PFP P1 HPLH2 |
| Synonyms name: |
Perforin perforin 1 (preforming protein) |
| Locus: |
10q22, 1 |
| Discovery year: |
1989-02-23 |
| GenBank acession: |
BC047695 |
| Entrez gene record: |
5551 |
| Pubmed identfication: |
1505959 2592021 |
| RefSeq identity: |
NM_005041 |
| Classification: |
C2 domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000018412 |
| Locus Specific Databases: |
PRF1base: Mutation registry for Familiar haemophagocytic lymphohistiocytosis, type II (FHL2) LRG_94 |