| Long name: |
DCTN1 Primary Polyclonal Antibody |
| Also known as: |
DCTN1 PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
DCTN1 |
| Specificity: |
This is a highly specific antibody against DCTN1 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human DCTN1/Dynactin 1 |
| Gene ID number: |
1639 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
ALS is a neurodegenerative disorder affecting upper and lower motor neurons, Brain, Death usually occurs within 2 to 5 years, Defects in DCTN1 are the cause of distal hereditary motor neuronopathy type 7B (HMN7B), Distal hereditary motor neuronopathies constitute a heterogeneous group of neuromuscular disorders caused by selective degeneration of motor neurons in the anterior horn of the spinal cord, Dynein-dynactin interaction is a key component of the mechanism of axonal transport of vesicles and organelles, HMN7B is a neuromuscular disorder, Later on, Parkinsonism develops later and respiratory failure occurred terminally, Perry syndrome is a neuropsychiatric disorder characterized by mental depression not responsive to antidepressant drugs or electroconvulsive therapy, Sensory abnormalities are absent, The disease starts with weakness and wasting of distal muscles of the anterior tibial and peroneal compartments of the legs, The etiology is likely to be multifactorial, The overall clinical picture consists of a classical distal muscular atrophy syndrome in the legs without clinical sensory loss, also called parkinsonism with alveolar hypoventilation and mental depression, also known as progressive lower motor neuron disease (PLMND), and resulting in fatal paralysis, exhaustion and marked weight loss, involving both genetic and environmental factors, sleep disturbances, weakness and atrophy may expand to the proximal muscles of the lower limbs and/or to the distal upper limbs, without sensory deficit in the posterior horn, Defects in DCTN1 are a cause of susceptibility to amyotrophic lateral sclerosis (ALS), Defects in DCTN1 are the cause of Perry syndrome (PERRYS), Involvement in disease, Required for the cytoplasmic dynein-driven retrograde movement of vesicles and organelles along microtubules, Tissue specificity |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
150 kDa dynein-associated polypeptide, DAP 150, DAP-150, DAP150, DCTN 1, DCTN1, DCTN1_HUMAN, DP 150, DP-150, DP150, Dynactin 1, Dynactin 1 p150 Glued Drosophila homolog, Dynactin 1 p150 glued homolog Drosophila, Dynactin subunit 1, Dynactin1, HMN7B, P135, p150 Glued Drosophila homolog, p150 glued, p150 glued homolog, p150-glued, p150GLUED DROSOPHILA HOMOLOG OF, p150glued, Alternative names150 kDa dynein associated polypeptide |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
DCTN1 |
| Short name: |
DCTN1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
DCTN1 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
2711 |
| Gene: |
DCTN1 |
More about : DCTN1 |
| Long gene name: |
dynactin subunit 1 |
| Synonyms gene name: |
Glued (Drosophila) homolog) , dynactin 1 (p150 |
| Synonyms name: |
p150 glued homolog (Drosophila) |
| Locus: |
2p13, 1 |
| Discovery year: |
1995-10-03 |
| Entrez gene record: |
1639 |
| Pubmed identfication: |
1828535 |
| RefSeq identity: |
NM_004082 |
| Classification: |
Dynactin |
| Havana BLAST/BLAT: |
OTTHUMG00000129963 |
| Locus Specific Databases: |
Inherited Peripheral Neuropathies Mutation Database ALSOD, the Amyotrophic Lateral Sclerosis Online Genetic Database LRG_237 |