| Long name: |
PRDM1 Primary Polyclonal Antibody |
| Also known as: |
PRDM1 PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
PRDM1 |
| Specificity: |
This is a highly specific antibody against PRDM1 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human PRDM1/Blimp1 |
| Gene ID number: |
144423 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Alone, Blimp-1 is a transcriptional repressor that localizes to the nucleus and is considered a master regulator of terminal B-cell development, Blimp-1 is expressed during the late stages of B-cell differentiation in immunoglobulin-secreting plasma cells, Blimp-1 is sufficient to trigger terminal B-cell differentiation, Blimp-1 upregulates the expression of syndecan-1 and J chain, The expression of Blimp-1 defines a checkpoint beyond which fully activated B cells proceed to the plasma cell stage, also designated PRDI-BF1), are induced by Blimp-1 (B lymphocyte-induced maturation protein, as well as in long-lived, bone marrow plasma cells, represses IFN-b gene transcription and associates with HDAC to recruit it to DNA, thereby repressing c-myc, whereas immature and partially activated cells are eliminated, which are terminally differentiated B-cells, The development and differentiation of plasma cells |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
B Lymphocyte Induced Maturation Protein 1, BLIMP-1, BLIMP1, Beta interferon gene positive regulatory domain I binding factor, Beta-interferon gene positive regulatory domain I-binding factor, Blimp-1, PR Domain Containing 1, PR domain containing 1 with ZNF domain, PR domain containing 1 with ZNF domain isoform 2, PR domain containing protein 1, PR domain zinc finger protein 1, PR domain-containing protein 1, PRDI BF1, PRDI binding factor 1, PRDI-BF1, PRDI-binding factor 1, PRDM 1, PRDM1_HUMAN, Positive Regulatory Domain I Binding Factor 1, Positive regulatory domain I-binding factor 1, Prdm1, Blimp 1 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
PRDM1 |
| Short name: |
PRDM1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
PRDM1 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
9346 |
| Gene: |
PRDM1 |
More about : PRDM1 |
| Long gene name: |
PR/SET domain 1 |
| Synonyms gene: |
BLIMP1 |
| Synonyms gene name: |
PR domain containing 1, with ZNF domain PR domain 1 |
| Synonyms: |
PRDI-BF1 |
| Locus: |
6q21 |
| Discovery year: |
1994-09-14 |
| Entrez gene record: |
639 |
| Pubmed identfication: |
1851123 |
| Classification: |
Zinc fingers C2H2-type PR/SET domain family |
| Havana BLAST/BLAT: |
OTTHUMG00000015299 |