| Long name: |
HRP Conjugated, HIF3 alpha Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
HRP Conjugated |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
H3 alpha |
| Specificity: |
This is a highly specific antibody against H3 alpha |
| Modification: |
Unmodified |
| Modification site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen_range: |
161-200/669 |
| Subcellular location: |
Nucleus, Cytoplasm |
| Source: |
KLH conjugated synthetic peptide derived from human HIF3 alpha |
| Gene ID number: |
64344 |
| Swiss Prot: |
Q9Y2N7 |
| Tested applications: |
IHC-P, WB |
| Recommended dilutions: |
IHC-P(1:100-500), WB(1:100-1000) |
| Crossreactivity: |
Mouse, Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
Binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters, Conversely, Functions as an inhibitor of angiogenesis in the cornea (By similarity), Hypoxia induces down-regulation of isoform 4, Isoform 4 attenuates the binding of HIF1A to hypoxia-responsive elements (HRE), Isoform 4 has a dominant-negative function of inactivating HIF1A-mediated transcription, Isoform 4 may be a negative regulator of hypoxia-inducible gene expression in the kidney and may be involved in renal tumorigenesis, Suppresses hypoxia-inducible expression of HIF1A and EPAS1, The complex HIF3A-ARNT activates the transcription of reporter genes driven by HRE, leading to activation of HIF1A in hypoxia, the expression of isoform 4 increases and thereby secure an inhibition of HIF1A activity, thus inhibiting HRE-driven transcription, upon restoring normoxia, Involved in adaptive response to hypoxia |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% Gentamicin, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Synonyms: |
Basic-helix-loop-helix-PAS protein MOP7, Class E basic helix-loop-helix protein 17, HIF-3-alpha, HIF-3A, HIF3-alpha, HIF3-alpha-1, HIF3A, Hypoxia-inducible factor 3-alpha, Inhibitory PAS domain protein, MOP7, Member of PAS protein 7, PAS domain-containing protein 7, PASD7, bHLHe17, IPAS |
| Properties: |
Also monoclonal HRP conjugates are often used for Western Blot, HRP conjugates are often primary rabbit polyclonal antibodies couples to the , found in the roots of , (HRP), C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°, enzyme , horseradish, horseradish peroxidase |
| Gene target: |
HIF3 alpha Conjugated |
| Short name: |
Conjugated, HIF3 alpha Antibody |
| Technique: |
antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
HRP |
| Alternative name: |
horseradish peroxidase coupled, HIF3 a (Antibody to) |
| Alternative technique: |
antibodies |