| Long name: |
Prominin 2 Primary Polyclonal Antibody |
| Also known as: |
Prominin 2 PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
Prominin 2 |
| Specificity: |
This is a highly specific antibody against Prominin 2 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
315-365/834 |
| Subcellular location: |
Extracellular |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Prominin 2 |
| Gene ID number: |
150696 |
| Swiss Prot: |
Q8N271 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Like Prominin 1, Prominin 2 expression is likely to be involved in growth suppression in the prostate, Similar to Prominin1 localization, and all along the digestive track and other epithelial tissues, and down-regulation of Prominin 2 may disrupt normal prostatic homeostasis and lead to uncontrolled prostatic growth, but their genomic organization is strikingly similar, suggesting a tumor suppressive role for Prominin 2, the Prominin 2 is also associated with membrane protrusions of the epithelial cells from adult kidney, the prominin 2 exhibit similar membrane topology with 5 trans-membrane domains and two large glycosylated extracellular domains, Prominin 2 expression is down-regulated in aggressive prostate cancer cell lines and transient transfection of PROML2 expression vectors has been shown to induce apoptosis in cultured prostate cancer cells, Prominin 2 is a 112 kDa glycoporotein structurally related to Prominin 1 (CD133) although amino acid similarity is not more than 30% |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
PROM-2, PROM2, Prominin-2, Prominin-like protein 2, UNQ2521/PRO6014, hPROML2, PROML2 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
Prominin 2 |
| Short name: |
Prominin 2 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
Prominin 2 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
20685 |
| Gene: |
PROM2 |
More about : PROM2 |
| Long gene name: |
prominin 2 |
| Locus: |
2q11, 1 |
| Discovery year: |
2003-03-25 |
| GenBank acession: |
AF245303 |
| Entrez gene record: |
150696 |
| Pubmed identfication: |
12514187 |
| RefSeq identity: |
NM_144707 |
| Havana BLAST/BLAT: |
OTTHUMG00000130393 |