| Long name: |
ALEXA FLUOR 350 Conjugated, RIPK-1 Polyclonal Antibody |
| Also known as: |
Anti-RIPK-1 PAb ALEXA FLUOR 350 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
350, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
RIPK-1 |
| Specificity: |
This is a highly specific antibody against RIPK-1 |
| Modification: |
Unmodified |
| Modification Site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
600-650/671 |
| Subcellular location: |
Cell membrane, Cytoplasm |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human RIPK-1/RIP |
| Gene ID Number: |
8737 |
| Swiss Prot: |
Q13546 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
Interaction with other cellular RHIM-containing adapters initiates gene activation and cell death, Phosphorylates DAB2IP at 'Ser-728' in a TNF-alpha-dependent manner, Polyubiquitinated protein binds to IKBKG/NEMO, RIPK1 and RIPK3 association, TRADD and TRAF2 are recruited to the receptor, Ubiquitination by TRAF2 via 'Lys-63'-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, Upon activation of TNFR1 by the TNF-alpha family cytokines, a critical event for NF-kappa-B activation, activation of pathogen recognition receptors (PRRs), and DNA damage, and thereby activates the MAP3K5-JNK apoptotic cascade, forms a necrosis-inducing complex, in particular, the regulatory subunit of the IKK complex, which in turn mediate downstream events including the activation of genes encoding inflammatory molecules, Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptors ligation |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
343nm/442nm |
| Synonyms: |
Cell death protein RIP, RIP-1, RIP1, RIPK1, Receptor-interacting protein 1, Receptor-interacting serine/threonine-protein kinase 1, Serine/threonine-protein kinase RIP, RIP |
| Properties: |
ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 350 conjugates can be used in multi-color flow cytometry with FACS's equipped with a second red laser or red diode, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
ALEXA FLUOR 350, Alexa Fluor |
| Gene target: |
RIPK-1 |
| Short name: |
RIPK-1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 350 |
| Alternative name: |
ALEXA FLUOR 350, RIPK-1 (Antibody to) |
| Alternative technique: |
antibodies |