| Long name: |
ALEXA FLUOR 647 Conjugated, ERK5 (Ser731+Thr733) Polyclonal Antibody |
| Also known as: |
Anti-ERK5 Ser731+Thr733 PAb ALEXA FLUOR 647 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
647, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
ERK5 Ser731+Thr733 |
| Specificity: |
This is a highly specific antibody against ERK5 Ser731+Thr733 |
| Modification: |
Phosphorylation |
| Modification Site: |
Ser731+Thr733 |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
725-740/816 |
| Subcellular location: |
Nucleus, Cytoplasm |
| Source: |
KLH conjugated synthetic phosphopeptide derived from human ERK5 around the phosphorylation sites of Ser731+Thr733 |
| Gene ID Number: |
5598 |
| Swiss Prot: |
Q13164 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway, Involved in the regulation of p53/TP53 by disrupting the PML-MDM2 interaction, MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways, May be important for endothelial function and maintenance of blood vessel integrity, May have a role in muscle cell differentiation, Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell cycle progression, The upstream activator of MAPK7 is the MAPK kinase MAP2K5, Upon activation, differentiation and cell survival, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C, Plays a role in various cellular processes such as proliferation |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
650nm/665nm |
| Synonyms: |
BMK1 ERK5 |
| Properties: |
ALEXA FLUOR made this Alexa Fluor 633 conjugate that can be used in multi-color flow cytometry with instruments equipped with a second red laser or red diode, ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 633 is a practical alternative to APC as well as Cy5, Bioss Primary Conjugated Antibodies, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, It is detected in the FL4 detector of the core's upgraded 2-laser FACScans, Like other Alexa Fluor dyes, exhibits uncommon photo stability, making it an ideal choice for fluorescent microscopy, the ERK5 (Ser731+Thr733) Antibody, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
ALEXA FLUOR 647, Alexa Fluor |
| Gene target: |
ERK5 (Ser731+Thr733) |
| Short name: |
ERK5 (Ser731+Thr733) Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 647 |
| Alternative name: |
ALEXA FLUOR 647, ERK5 (Ser731+Thr733) (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
6880 |
| Gene: |
MAPK7 |
More about : MAPK7 |
| Long gene name: |
mitogen-activated protein kinase 7 |
| Synonyms gene: |
PRKM7 |
| Synonyms name: |
BMK1 kinase extracellular-signal-regulated kinase 5 |
| Locus: |
17p11, 2 |
| Discovery year: |
1998-04-28 |
| GenBank acession: |
U25278 |
| Entrez gene record: |
5598 |
| Pubmed identfication: |
10072598 7759517 |
| RefSeq identity: |
NM_139033 |
| Classification: |
Mitogen-activated protein kinases |
| Havana BLAST/BLAT: |
OTTHUMG00000059587 |