| Long name: |
ALEXA FLUOR 488 Conjugated, Claudin 14 Polyclonal Antibody |
| Also known as: |
Anti-Claudin 14 PAb ALEXA FLUOR 488 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
488, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
Claudin 14 |
| Specificity: |
This is a highly specific antibody against Claudin 14 |
| Modification: |
Unmodified |
| Modification Site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Subcellular location: |
Extracellular |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Claudin 14 |
| Tested applications: |
IF(IHC-P), FCM |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), FCM(1:20-100) |
| Crossreactivity: |
Mouse, Rat, Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
Claudin expression is often highly restricted to specfic regions of different tissues and may have an important role in transcellular transport through tight junctions, Claudin-14 is a multi-pass membrane protein that is expressed in liver, Claudins, Claudins are located in both epithelial and endothelial cells in all tight junction-bearing tissues, Defects in the gene encoding claudin-14 are the cause of non-syndromic sensorineural deafness autosomal recessive type 29 (DFNB29), Occludin and Junction adhesion molecules, These proteins are important structural and functional components of tight junctions in paracellular transport, Three classes of proteins are known to localize to tight junctions, a form of hearing loss resulting from damage to either nerve pathways or neural receptors of the inner ear, including the claudins, kidney and ear, make up tight junction strands, which consist of four transmembrane domains and two extracellular loops, The Claudin superfamily consists of many structurally related proteins in humans |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
499nm/519nm |
| Properties: |
ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 488 has the same range to that of fluorescein isothiocyanate (FITC), Also Alexa Fluor 488 is pH stable, As a result of this photo stability, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, It is distinguished in the FL1 of a FACS-Calibur or FACScan, has a very high photo stability, it has turned into an antibody for fluorescent microscopy and FACS FLOW cytometry, yet the Claudin 14 Antibody, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Gene target: |
Claudin 14 |
| Short name: |
Claudin 14 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 488 |
| Alternative name: |
ALEXA FLUOR 488, Claudin 14 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
2035 |
| Gene: |
CLDN14 |
More about : CLDN14 |
| Long gene name: |
claudin 14 |
| Synonyms gene: |
DFNB29 |
| Locus: |
21q22, 13 |
| Discovery year: |
1999-11-26 |
| GenBank acession: |
AJ132445 |
| Entrez gene record: |
23562 |
| Pubmed identfication: |
11163249 |
| RefSeq identity: |
NM_144492 |
| Classification: |
Claudins Deafness associated genes |
| Havana BLAST/BLAT: |
OTTHUMG00000086638 |
| Locus Specific Databases: |
Hereditary Hearing Loss Homepage |