| Long name: |
ALEXA FLUOR 647 Conjugated, SMN1 Polyclonal Antibody |
| Also known as: |
Anti-SMN1 PAb ALEXA FLUOR 647 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
647, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
SMN1 |
| Specificity: |
This is a highly specific antibody against SMN1 |
| Modification: |
Unmodified |
| Modification Site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
60-95/294 |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human SMN1 |
| Gene ID Number: |
6606 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
2a, 2b, Four transcript variants encoding distinct isoforms have been described, It is thought that gene conversion events may involve the two genes, Note that the nine exons of both the telomeric and centromeric copies are designated historically as exon 1, The critical sequence difference between the two genes is a single nucleotide in exon 7, The full length protein encoded by this gene localizes to both the cytoplasm and the nucleus, The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region, The telomeric and centromeric copies of this gene are nearly identical and encode the same protein, This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions, This gene may be a modifier of disease caused by mutation in the telomeric copy, This protein forms heteromeric complexes with proteins such as SIP1 and GEMIN4, While mutations in the telomeric copy are associated with spinal muscular atrophy, Within the nucleus, and 3-8, and also interacts with several proteins known to be involved in the biogenesis of snRNPs, do not lead to disease, leading to varying copy numbers of each gene, mutations in this gene, such as hnRNP U protein and the small nucleolar RNA binding protein, the centromeric copy, the protein localizes to subnuclear bodies called gems which are found near coiled bodies containing high concentrations of small ribonucleoproteins (snRNPs), which is thought to be an exon splice enhancer, SMN1 is part of a 500 kb inverted duplication on chromosome 5q13 |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
650nm/665nm |
| Synonyms: |
BCD541 SMNT SMA1 SMA2 SMA3 GEMIN1 TDRD16A |
| Properties: |
ALEXA FLUOR made this Alexa Fluor 633 conjugate that can be used in multi-color flow cytometry with instruments equipped with a second red laser or red diode, ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 633 is a practical alternative to APC as well as Cy5, Bioss Primary Conjugated Antibodies, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, It is detected in the FL4 detector of the core's upgraded 2-laser FACScans, Like other Alexa Fluor dyes, exhibits uncommon photo stability, making it an ideal choice for fluorescent microscopy, the SMN1 Antibody, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
ALEXA FLUOR 647, Alexa Fluor |
| Gene target: |
SMN1 |
| Short name: |
SMN1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 647 |
| Alternative name: |
ALEXA FLUOR 647, SMN1 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
11117 |
| Gene: |
SMN1 |
More about : SMN1 |
| Long gene name: |
survival of motor neuron 1, telomeric |
| Synonyms gene: |
SMA@ SMA |
| Synonyms gene name: |
Kugelberg-Welander disease) , spinal muscular atrophy (Werdnig-Hoffmann disease |
| Synonyms name: |
gemin-1 tudor domain containing 16A |
| Locus: |
5q13, 2 |
| Discovery year: |
1996-12-12 |
| GenBank acession: |
U18423 |
| Entrez gene record: |
6606 |
| Pubmed identfication: |
7813012 |
| RefSeq identity: |
NM_000344 |
| Classification: |
Tudor domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000099361 |
| Locus Specific Databases: |
SMN1 - Spinal Muscular Atrophy (SMA) Leiden Muscular Dystrophy pages ALSOD, the Amyotrophic Lateral Sclerosis Online Genetic Database LRG_676 |