| Long name: |
Cy3 Conjugated, KDM1A Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
cy3 conjugation kit |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
KDM1A |
| Specificity: |
This is a highly specific antibody against KDM1A |
| Modification: |
Unmodified |
| Modification site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen_range: |
120-170/852 |
| Subcellular location: |
Nucleus |
| Source: |
KLH conjugated synthetic peptide derived from human KDM1A |
| Gene ID number: |
23028 |
| Swiss Prot: |
O60341 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
Acts as a corepressor by mediating demethylation of H3K4me, Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed, Alone, Also acts as a coactivator of androgen receptor (ANDR)-dependent transcription, CDN7 and KRT8, Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, Demethylates and stabilizes the DNA methylase DNMT1, Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me, Demethylates di-methylated 'Lys-370' of p53/TP53 which prevents interaction of p53/TP53 with TP53BP1 and represses p53/TP53-mediated transcriptional activation, Effector of SNAI1-mediated transcription repression of E-cadherin/CDH1, May play a role in the repression of neuronal genes, Required for gastrulation during embryogenesis, Required for the maintenance of the silenced state of the SNAI1 target genes E-cadherin/CDH1 and CDN7, The presence of PRKCB in ANDR-containing complexes, a number of genes implicated in multilineage blood cell development, a specific tag for epigenetic transcriptional activation, a specific tag for epigenetic transcriptional repression, a specific tag that prevents demethylation H3K4me, by being recruited to ANDR target genes and mediating demethylation of H3K9me, depending on the context, it is unable to demethylate H3K4me on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity, prevents H3K4me demethylase activity of KDM1A, thereby acting as a coactivator or a corepressor, via histone deacetylase (HDAC) recruitment, which mediates phosphorylation of 'Thr-6' of histone H3 (H3T6ph), Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3 |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Excitation Emission: |
512, 550nm/570, 615nm |
| Synonyms: |
KIAA0601 BHC110 LSD1 |
| Properties: |
1 of the KDM1A Antibody, Conjugated can be used in flow cytometry but typically shows lower fluorescence intensity comparable to that of PE or APC, Cy3 antibodies are excited by the 488-nanometer wave of an argon laser and the 633-nanometer line of a helium-neon diode laser, This Bioss Primary Conjugated Antibodies antibody is well suited for fluorescent microscopy, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
KDM1A Conjugated |
| Short name: |
Conjugated, KDM1A Antibody |
| Technique: |
antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
Cy3 |
| Alternative name: |
cyanine 3 coupled, KDM1A (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
29079 |
| Gene: |
KDM1A |
More about : KDM1A |
| Long gene name: |
lysine demethylase 1A |
| Synonyms gene: |
AOF2 KDM1 |
| Synonyms gene name: |
amine oxidase (flavin containing) domain 2 lysine (K)-specific demethylase 1 |
| Locus: |
1p36, 12 |
| Discovery year: |
2004-02-26 |
| GenBank acession: |
AL031428 |
| Entrez gene record: |
23028 |
| Pubmed identfication: |
9628581 12493763 |
| RefSeq identity: |
NM_015013 |
| Classification: |
Lysine demethylases |
| Havana BLAST/BLAT: |
OTTHUMG00000003220 |