| Long name: |
ALEXA FLUOR 647 Conjugated, Tuberin Polyclonal Antibody |
| Also known as: |
Anti-Tuberin PAb ALEXA FLUOR 647 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
647, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
Tuberin |
| Specificity: |
This is a highly specific antibody against Tuberin |
| Modification: |
Unmodified |
| Modification Site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
1600-1650/1809 |
| Subcellular location: |
Cytoplasm |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Tuberin |
| Gene ID Number: |
7249 |
| Swiss Prot: |
P49815 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, Implicated as a tumor suppressor, Involved in microtubule-mediated protein transport, Mutations in TSC2 lead to constitutive activation of RAP1A in tumors, Stimulates weakly the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 in vitro, a direct activator of the protein kinase activity of mTORC1, but this seems to be due to unregulated mTOR signaling, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling, In complex with TSC1 |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
650nm/665nm |
| Synonyms: |
tuberin LAM PPP1R160 TSC2 |
| Properties: |
ALEXA FLUOR made this Alexa Fluor 633 conjugate that can be used in multi-color flow cytometry with instruments equipped with a second red laser or red diode, ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 633 is a practical alternative to APC as well as Cy5, Bioss Primary Conjugated Antibodies, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, It is detected in the FL4 detector of the core's upgraded 2-laser FACScans, Like other Alexa Fluor dyes, exhibits uncommon photo stability, making it an ideal choice for fluorescent microscopy, the Tuberin Antibody, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
ALEXA FLUOR 647, Alexa Fluor |
| Gene target: |
Tuberin |
| Short name: |
Tuberin Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 647 |
| Alternative name: |
ALEXA FLUOR 647, Tuberin (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
12365 |
| Gene: |
TSC4 |
More about : TSC4 |
| Long gene name: |
tuberous sclerosis 2 |
| Synonyms name: |
protein phosphatase 1, regulatory subunit 160 |
| Locus: |
16p13, 3 |
| Discovery year: |
1989-05-25 |
| GenBank acession: |
AB014460 |
| Entrez gene record: |
7249 |
| Pubmed identfication: |
1303246 7558029 |
| RefSeq identity: |
NM_000548 |
| Classification: |
Protein phosphatase 1 regulatory subunits |
| Havana BLAST/BLAT: |
OTTHUMG00000128745 |
| Locus Specific Databases: |
TSC2 Mutation Database Tuberous sclerosis database LRG_487 |