| Long name: |
LRP6 (Ser1490) Primary Polyclonal Antibody |
| Also known as: |
LRP6 (Ser1490) PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
LRP6 Ser1490 |
| Specificity: |
This is a highly specific antibody against LRP6 Ser1490 |
| Modification(s): |
Phosphorylation |
| Modification site(s): |
Ser1490 |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
1470-1520/1613 |
| Subcellular location: |
Cytoplasm |
| Source: |
KLH conjugated synthetic phosphopeptide derived from human LRP6 around the phosphorylation site of Ser1490 |
| Gene ID number: |
4040 |
| Swiss Prot: |
O75581 |
| Tested Applications: |
IF(ICC), IF(IHC-P), IHC-P |
| Recommended dilutions: |
IF(ICC)(1:50-200), IF(IHC-P)(1:50-200), IHC-P(1:100-500) |
| Cross reactivity: |
Mouse, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Cell-surface coreceptor of Wnt/beta-catenin signaling, Required for posterior patterning of the epiblast during gastrulation (By similarity), The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin, which plays a pivotal role in bone formation, Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
LRP-6, LRP6, Low-density lipoprotein receptor-related protein 6, ADCAD2 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
LRP6 (Ser1490) |
| Short name: |
LRP6 (Ser1490) Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
low density lipoprotein receptor-related protein 6 (Ser1490) (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
ADCAD2, Cell surfaces, DNA-templated and biological process this GO :0006469 and negative regulation of protein kinase activity and biological process this GO :0007204 and positive regulation of cytosolic calcium ion concentration and biological process this GO :0007268 and synaptic transmission and biological process this GO :0009880 and embryonic pattern specification and biological process this GO :0009950 and dorsal/ventral axis specification and biological process this GO :0009952 and anterior/posterior pattern specification and biological process this GO :0009986 and cell surface and cellular component this GO :0014029 and neural crest formation and biological process this GO :0014033 and neural crest cell differentiation and biological process this GO :0016020 and membrane and cellular component this GO :0016021 and integral component of membrane and cellular component this GO :0016055 and Wnt signaling pathway and biological process this GO :0016337 and single organismal cell-cell adhesion and biological process this GO :0017147 and Wnt-protein binding and molecular function this GO :0019210 and kinase inhibitor activity and molecular function this GO :0019534 and toxin transporter activity and molecular function this GO :0021587 and cerebellum morphogenesis and biological process this GO :0021794 and thalamus development and biological process this GO :0021795 and cerebral cortex cell migration and biological process this GO :0021861 and forebrain radial glial cell differentiation and biological process this GO :0021872 and forebrain generation of neurons and biological process this GO :0021874 and Wnt receptor signaling pathway involved in forebrain neuroblast division and biological process this GO :0021915 and neural tube development and biological process this GO :0021943 and formation of radial glial scaffolds and biological process this GO :0021987 and cerebral cortex development and biological process this GO :0030178 and negative regulation of Wnt signaling pathway and biological process this GO :0030278 and regulation of ossification and biological process this GO :0030326 and embryonic limb morphogenesis and biological process this GO :0030900 and forebrain development and biological process this GO :0030901 and midbrain development and biological process this GO :0030917 and midbrain-hindbrain boundary development and biological process this GO :0031410 and cytoplasmic vesicle and cellular component this GO :0034185 and apolipoprotein binding and molecular function this GO :0034392 and negative regulation of smooth muscle cell apoptotic process and biological process this GO :0035108 and limb morphogenesis and biological process this GO :0035115 and embryonic forelimb morphogenesis and biological process this GO :0035116 and embryonic hindlimb morphogenesis and biological process this GO :0035261 and external genitalia morphogenesis and biological process this GO :0036342 and post-anal tail morphogenesis and biological process this GO :0042074 and cell migration involved in gastrulation and biological process this GO :0042127 and regulation of cell proliferation and biological process this GO :0042475 and odontogenesis of dentin-containing tooth and biological process this GO :0042733 and embryonic digit morphogenesis and biological process this GO :0042802 and identical protein binding and molecular function this GO :0042803 and protein homodimerization activity and molecular function this GO :0042813 and Wnt-activated receptor activity and molecular function this GO :0043025 and neuronal cell body and cellular component this GO :0043065 and positive regulation of apoptotic process and biological process this GO :0043235 and receptor complex and cellular component this GO :0043434 and response to peptide hormone and biological process this GO :0044332 and Wnt signaling pathway involved in dorsal/ventral axis specification and biological process this GO :0044335 and canonical Wnt receptor signaling pathway involved in neural crest cell differentiation and biological process this GO :0044340 and canonical Wnt signaling pathway involved in regulation of cell proliferation and biological process this GO :0045202 and synapse and cellular component this GO :0045598 and regulation of fat cell differentiation and biological process this GO :0045599 and negative regulation of fat cell differentiation and biological process this GO :0045778 and positive regulation of ossification and biological process this GO :0045780 and positive regulation of bone resorption and biological process this GO :0045787 and positive regulation of cell cycle and biological process this GO :0045893 and positive regulation of transcription, DNA-templated and biological process this GO :0045944 and positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0046849 and bone remodeling and biological process this GO :0048596 and embryonic camera-type eye morphogenesis and biological process this GO :0048699 and generation of neurons and biological process this GO :0048705 and skeletal system morphogenesis and biological process this GO :0050680 and negative regulation of epithelial cell proliferation and biological process this GO :0051091 and positive regulation of sequence-specific DNA binding transcription factor activity and biological process this GO :0051593 and response to folic acid and biological process this GO :0060021 and palate development and biological process this GO :0060026 and convergent extension and biological process this GO :0060042 and retina morphogenesis in camera-type eye and biological process this GO :0060059 and embryonic retina morphogenesis in camera-type eye and biological process this GO :0060070 and canonical Wnt signaling pathway and biological process this GO :0060284 and regulation of cell development and biological process this GO :0060325 and face morphogenesis and biological process this GO :0060349 and bone morphogenesis and biological process this GO :0060444 and branching involved in mammary gland duct morphogenesis and biological process this GO :0060535 and trachea cartilage morphogenesis and biological process this GO :0060596 and mammary placode formation and biological process this GO :0060603 and mammary gland duct morphogenesis and biological process this GO :0061310 and canonical Wnt receptor signaling pathway involved in cardiac neural crest cell differentiation involved in heart development and biological process this GO :0061324 and canonical Wnt receptor signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation and biological process this GO :0071397 and cellular response to cholesterol and biological process this GO :0071542 and dopaminergic neuron differentiation and biological process this GO :0071901 and negative regulation of protein serine/threonine kinase activity and biological process this GO :0071936 and coreceptor activity involved in Wnt receptor signaling pathway and molecular function this GO :0090009 and primitive streak formation and biological process this GO :0090118 and receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport and biological process this GO :0090244 and Wnt signaling pathway involved in somitogenesis and biological process this GO :0090245 and axis elongation involved in somitogenesis and biological process this GO :0090263 and positive regulation of canonical Wnt signaling pathway and biological process this GO :1901998 and toxin transport and biological process this GO :2000051 and negative regulation of non-canonical Wnt signaling pathway and biological process this GO :2000055 and positive regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification and biological process this GO :2000149 and negative regulation of planar cell polarity pathway involved in ventricular septum morphogenesis and biological process this GO :2000151 and negative regulation of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis and biological process this GO :2000162 and negative regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesis and biological process this GO :2000164 and negative regulation of planar cell polarity pathway involved in outflow tract morphogenesis and biological process this GO :2000166 and negative regulation of planar cell polarity pathway involved in pericardium morphogenesis and biological process this GO :2000168 and negative regulation of planar cell polarity pathway involved in neural tube closure and biological process, LRP6 and IDBG-20075 and ENSG00000070018 and 4040, LRP6 and IDBG-639434 and ENSBTAG00000011761 and 536328, Lrp6 and IDBG-194033 and ENSMUSG00000030201 and 102642234, coreceptor activity involved in Wnt receptor signaling pathway, this GO :0001702 and gastrulation with mouth forming second and biological process this GO :0001756 and somitogenesis and biological process this GO :0001843 and neural tube closure and biological process this GO :0001933 and negative regulation of protein phosphorylation and biological process this GO :0001947 and heart looping and biological process this GO :0002053 and positive regulation of mesenchymal cell proliferation and biological process this GO :0003344 and pericardium morphogenesis and biological process this GO :0003401 and axis elongation and biological process this GO :0005041 and low-density lipoprotein receptor activity and molecular function this GO :0005102 and receptor binding and molecular function this GO :0005109 and frizzled binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005769 and early endosome and cellular component this GO :0005783 and endoplasmic reticulum and cellular component this GO :0005794 and this GO lgi apparatus and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0005901 and caveola and cellular component this GO :0006355 and regulation of transcription, this GO :0005041 : low-density lipoprotein receptor activity, this GO :0005041 : low-density lipoprotein receptor activity and also this GO :0005102 : receptor binding and also this GO :0005109 : frizzled binding and also this GO :0005515 : protein binding and also this GO :0017147 : Wnt-protein binding and also this GO :0019210 : kinase inhibitor activity and also this GO :0019534 : toxin transporter activity and also this GO :0034185 : apolipoprotein binding and also this GO :0042802 : identical protein binding and also this GO :0042803 : protein homodimerization activity and also this GO :0042813 : Wnt-activated receptor activity and also this GO :0071936 : coreceptor activity involved in Wnt receptor signaling pathway, this GO :0005102 : receptor binding, this GO :0005109 : frizzled binding, this GO :0005515 : protein binding, this GO :0017147 : Wnt-protein binding, this GO :0019210 : kinase inhibitor activity, this GO :0019534 : toxin transporter activity, this GO :0034185 : apolipoprotein binding, this GO :0042802 : identical protein binding, this GO :0042803 : protein homodimerization activity, this GO :0042813 : Wnt-activated receptor activity, this GO :0071936 : coreceptor activity involved in Wnt receptor signaling pathway, 16974, low density lipoprotein receptor-related protein 6 |
| Identity: |
6698 |
| Gene: |
LRP6 |
More about : LRP6 |
| Long gene name: |
LDL receptor related protein 6 |
| Synonyms gene name: |
low density lipoprotein receptor-related protein 6 |
| Synonyms: |
ADCAD2 |
| Locus: |
12p13, 2 |
| Discovery year: |
1998-04-07 |
| GenBank acession: |
AF074264 |
| Entrez gene record: |
4040 |
| Pubmed identfication: |
9704021 |
| Classification: |
Low density lipoprotein receptors |
| Havana BLAST/BLAT: |
OTTHUMG00000168540 |