| Long name: |
HER3 (Tyr1222) Primary Polyclonal Antibody |
| Also known as: |
HER3 (Tyr1222) PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
HER3 Tyr1222 |
| Specificity: |
This is a highly specific antibody against HER3 Tyr1222 |
| Modification(s): |
Phosphorylation |
| Modification site(s): |
Tyr1222 |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
KLH conjugated synthetic phosphopeptide derived from human HER3 around the phosphorylation site of Tyr1222 [LG(p-Y)EY] |
| Gene ID number: |
2065 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Additional splice variants have also been reported but they have not been thoroughly characterized, Alternate transcriptional splice variants encoding different isoforms have been characterized, Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers including prostate, Defects in ERBB3 are the cause of lethal congenital contracture syndrome type 2 (LCCS2), ErbB3 is a membrane-bound protein which has a neuregulin binding domain but not an active kinase domain, Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation, However it does form heterodimers with other EGF receptor family members which do have kinase activity, Isoform 2 lacks the intermembrane region and is secreted outside the cell, It can therefore bind this ligand but cannot convey a signal into the cell via protein phosphorylation, LCCS2 is an autosomal recessive neurogenic form of a neonatally lethal arthrogryposis that is associated with atrophy of the anterior horn of the spinal cord, This form acts to modulate the activity of the membrane-bound form, also called Israeli Bedouin multiple contracture syndrome type A, bladder and breast tumors, ErbB3 is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
ERBB3, ERBB3 protein, ERBB3_HUMAN, ErbB 3 phospho Y1222, Glial growth factor receptor, HER 3, HER3, LCCS2, MDA BF 1, MGC88033, Receptor tyrosine protein kinase erbB 3, Receptor tyrosine protein kinase erbB3, Tyrosine kinase type cell surface receptor HER3, c erbB 3, c erbB3, erbB3 S, p-HRE3 Tyr1222, p180 ErbB3, p45 sErbB3, p85 sErbB3, proto-oncogene-like protein c ErbB 3, proto-oncogene-like protein c ErbB3, receptor tyrosine protein kinase ERB3, Her3/ErbB3Tyr1222 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
HER3 (Tyr1222) |
| Short name: |
HER3 (Tyr1222) Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
HER3 (Tyr1222) (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
3431 |
| Gene: |
ERBB3 |
More about : ERBB3 |
| Long gene name: |
erb-b2 receptor tyrosine kinase 3 |
| Synonyms gene: |
LCCS2 |
| Synonyms gene name: |
lethal congenital contracture syndrome 2 v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3 |
| Synonyms: |
HER3 |
| Synonyms name: |
human epidermal growth factor receptor 3 |
| Locus: |
12q13, 2 |
| Discovery year: |
1990-07-15 |
| GenBank acession: |
M34309 |
| Entrez gene record: |
2065 |
| RefSeq identity: |
NM_001982 |
| Classification: |
Erb-b2 receptor tyrosine kinases |
| Havana BLAST/BLAT: |
OTTHUMG00000170140 |
| Locus Specific Databases: |
LRG_996 |