| Long name: |
NEMO Primary Polyclonal Antibody |
| Also known as: |
NEMO PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
NEMO |
| Specificity: |
This is a highly specific antibody against NEMO |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
370-419/419 |
| Subcellular location: |
Nucleus, Cytoplasm |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human NEMO |
| Gene ID number: |
8517 |
| Swiss Prot: |
Q9Y6K9 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Also considered to be a mediator for TAX activation of NF-kappa-B, Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity, Essential for viral activation of IRF3, However, Involved in TLR3- and IFIH1-mediated antiviral innate response, Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways, the specific type of polyubiquitin recognized upon cell stimulation (either 'Lys-63'-linked or linear polyubiquitin) and its functional importance is reported conflictingly, this function requires 'Lys-27'-linked polyubiquitination, Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
AMCBX1, FIP-3, FIP3, Fip3p, I-kappa-B kinase subunit gamma, IKBKG, IKK-gamma, IKKAP1, IKKG, IMD33, IP1, IP2, IPD2, IkB kinase subunit gamma, IkB kinase-associated protein 1, Inhibitor of nuclear factor kappa-B kinase subunit gamma, NEMO, NF-kappa-B essential modifier, NF-kappa-B essential modulator, ZC2HC9, IP |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
NEMO |
| Short name: |
NEMO Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
NEMO (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
5961 |
| Gene: |
IKBKG |
More about : IKBKG |
| Long gene name: |
inhibitor of nuclear factor kappa B kinase subunit gamma |
| Synonyms gene: |
IP2 IP1 |
| Synonyms gene name: |
incontinentia pigmenti inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma |
| Synonyms: |
IKK-gamma NEMO Fip3p FIP-3 FIP3 ZC2HC9 |
| Locus: |
Xq28 |
| Discovery year: |
1998-09-30 |
| GenBank acession: |
AF074382 |
| Entrez gene record: |
8517 |
| Pubmed identfication: |
9751060 10087442 11590134 |
| RefSeq identity: |
NM_003639 |
| Classification: |
Zinc fingers C2HC-type |
| Havana BLAST/BLAT: |
OTTHUMG00000024234 |
| Locus Specific Databases: |
IKBKGbase: Mutation registry for Nemo deficiency Mental Retardation database LRG_70 |