P105 RB Antibody, ALEXA FLUOR 488

Catalog number:	bs-2777R-A488 Buy Now
Price:	350 €
Supplier:	Bioss Primary Conjugated Antibodies.
Product name:	P105 RB Antibody, ALEXA FLUOR 488
Quantity:	100ul
Related search:	antibody fluor gene antibodies complex histone nfkb promoter

More details Need more?:

Long name:	ALEXA FLUOR 488 Conjugated, P105 RB Polyclonal Antibody
Also known as:	Anti-P105 RB PAb ALEXA FLUOR 488
Category:	Conjugated Primary Antibodies
Conjugated with:	488, ALEXA FLUOR®
Host Organism:	Rabbit (Oryctolagus cuniculus)
Target Antigen:	P105 RB
Specificity:	This is a highly specific antibody against P105 RB
Modification:	Unmodified
Modification Site:	None
Clonality:	Polyclonal
Clone:	Polyclonal antibody
Concentration:	1ug per 1ul
Immunogen range:	68-116/928
Subcellular location:	Nucleus
Source:	This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Rb/P105 RB
Gene ID Number:	5925
Swiss Prot:	P06400
Tested applications:	IF(IHC-P)
Recommended dilutions:	IF(IHC-P)(1:50-200)
Crossreactivity:	Mouse, Rat, Human
Cross-reactive species details:	not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the antigen:	Acts as a transcription repressor of E2F1 target genes, Controls histone H4 'Lys-2' trimethylation, Directly involved in heterochromatin formation by maintaining overall chromatin structure and, HPV E7 protein or adenovirus E1A protein induce the disassembly of RB1-E2F1 complex thereby disrupting RB1's activity, In case of viral infections, In resting neurons, Inhibits the intrinsic kinase activity of TAF1, Mediates transcriptional repression by SMARCA4/BRG1 by recruiting a histone deacetylase (HDAC) complex to the c-FOS promoter, Promotes G-G1 transition when phosphorylated by CDK3/cyclin-C, RB1 is dephosphorylated by calcineurin, Recruits and targets histone methyltransferases SUV39H1, SUV42H1 and SUV42H2, The underphosphorylated, Upon calcium influx, active form of RB1 interacts with E2F1 and represses its transcription activity, in particular, interactions with SV4 large T antigen, leading to cell cycle arrest, leading to epigenetic transcriptional repression, that of constitutive heterochromatin by stabilizing histone methylation, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex, which leads to release of the repressor complex (By similarity), Key regulator of entry into cell division that acts as a tumor suppressor
Purification:	Purified by Protein A
Storage conditions:	50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA
Excitation emission:	499nm/519nm
Synonyms:	LYT-10 p52 p105 NF-kB2 p49/p100
Properties:	ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 488 has the same range to that of fluorescein isothiocyanate (FITC), Also Alexa Fluor 488 is pH stable, As a result of this photo stability, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, It is distinguished in the FL1 of a FACS-Calibur or FACScan, has a very high photo stability, it has turned into an antibody for fluorescent microscopy and FACS FLOW cytometry, yet the P105 RB Antibody, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate
Conjugation:	Alexa Fluor
Gene target:	P105 RB
Short name:	P105 RB Antibody
Technique:	antibodies against human proteins, antibodies for, Antibody
Label:	ALEXA FLUOR 488
Alternative name:	ALEXA FLUOR 488, P105 RB (Antibody to)
Alternative technique:	antibodies
Identity:	7795
Gene:	NFKB2 | More about : NFKB2
Long gene name:	nuclear factor kappa B subunit 2
Synonyms gene name:	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
Locus:	10q24, 32
Discovery year:	1991-11-14
GenBank acession:	X61498
Entrez gene record:	4791
Pubmed identfication:	1876189
Classification:	Ankyrin repeat domain containing NF-kappa B complex subunits
Havana BLAST/BLAT:	OTTHUMG00000018962

• #antibody
• #fluor
• #gene
• #antibodies
• #complex
• #histone
• #nfkb
• #promoter