| Long name: |
BLNK Primary Polyclonal Antibody |
| Also known as: |
BLNK PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
BLNK |
| Specificity: |
This is a highly specific antibody against BLNK |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
330-380/456 |
| Subcellular location: |
Cell membrane, Cytoplasm |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human BLNK |
| Gene ID number: |
29760 |
| Swiss Prot: |
Q8WV28 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
However, Important for the activation of NF-kappa-B and NFAT, MAP kinase p38 and JNK, May be required for the RAC1-JNK pathway, May play an important role in BCR-induced B-cell apoptosis, Modulates AP1 activation, Plays a critical role in orchestrating the pro-B cell to pre-B cell transition, Plays a role in the activation of ERK/EPHB2, Plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca(2+) mobilization and is required for trafficking of the BCR to late endosomes, bridging the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development, does not seem to be required for pre-BCR-mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling, downstream of the B-cell receptor (BCR), Functions as a central linker protein |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
AGM4, B-cell adapter containing a SH2 domain protein, B-cell adapter containing a Src homology 2 domain protein, B-cell linker protein, BASH, BLNK, BLNK-S, Cytoplasmic adapter protein, LY57, SLP-65, SLP65, Src homology 2 domain-containing leukocyte protein of 65 kDa, bca |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
BLNK |
| Short name: |
BLNK Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
B-cell linker (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
BLNK and IDBG-83724 and ENSG00000095585 and 29760, BT, Blnk and IDBG-165316 and ENSMUSG00000061132 and 17060, Plasma membranes, protein binding, this GO :0005068 and transmembrane receptor protein tyrosine kinase adaptor activity and molecular function this GO :0005070 and SH3/SH2 adaptor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005622 and intracellular and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0006954 and inflammatory response and biological process this GO :0006959 and humoral immune response and biological process this GO :0007169 and transmembrane receptor protein tyrosine kinase signaling pathway and biological process this GO :0009967 and positive regulation of signal transduction and biological process this GO :0030183 and B cell differentiation and biological process this GO :0035556 and intracellular signal transduction and biological process, this GO :0005068 : transmembrane receptor protein tyrosine kinase adaptor activity, this GO :0005068 : transmembrane receptor protein tyrosine kinase adaptor activity and also this GO :0005070 : SH3/SH2 adaptor activity and also this GO :0005515 : protein binding, this GO :0005070 : SH3/SH2 adaptor activity, this GO :0005515 : protein binding, 24520 and IDBG-638042 and ENSBTAG00000021358 and 510393, B-cell linker |
| Identity: |
14211 |
| Gene: |
BLNK |
More about : BLNK |
| Long gene name: |
B-cell linker |
| Synonyms: |
SLP65 Ly57 SLP-65 BLNK-s BASH bca |
| Synonyms name: |
B-cell adapter containing a SH2 domain protein B-cell activation Src homology [SH2] domain-containing leukocyte protein of 65 kD B cell adaptor containing SH2 domain |
| Locus: |
10q24, 1 |
| Discovery year: |
2001-07-16 |
| GenBank acession: |
AF068180 |
| Entrez gene record: |
29760 |
| Pubmed identfication: |
9697839 10583958 |
| RefSeq identity: |
NM_013314 |
| Classification: |
SH2 domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000018827 |
| Locus Specific Databases: |
BLNKbase: Mutation registry for BLNK deficiency LRG_21 |