| Long name: |
Cy5, 5 Conjugated, Lck/p56-LCK Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
Cy5, 5, 5, Cy5 |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
Lck/p56-LCK |
| Specificity: |
This is a highly specific antibody against Lck/p56-LCK |
| Modification: |
Unmodified |
| Modification site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
KLH conjugated synthetic peptide derived from human Lck |
| Gene ID number: |
3932 |
| Swiss Prot: |
P06239 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
Also plays a role in the IL2 receptor-linked signaling pathway that controls the T-cell proliferative response, Associates directly with the cytoplasmic tail of CD2, Association of the TCR with a peptide antigen-bound MHC complex facilitates the interaction of CD4 and CD8 with MHC class II and class I molecules, Binding of IL2 to its receptor results in increased activity of LCK, Constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors, Following this, Is expressed at all stages of thymocyte development and is required for the regulation of maturation events that are governed by both pre-TCR and mature alpha beta TCR, LCK also contributes to signaling by other receptor molecules, LCK then phosphorylates tyrosines residues within the immunoreceptor tyrosine-based activation motifs (ITAM) of the cytoplasmic tails of the TCR-gamma chains and CD3 subunits, Once stimulated, PTK2B/PYK2, Phosphorylates other substrates including RUNX3, Plays a key role in T-cell antigen receptor (TCR)-linked signal transduction pathways, RHOH or TYROBP, a large number of signaling molecules are recruited, initiating the TCR/CD3 signaling pathway, respectively, that becomes phosphorylated and activated by LCK, the TCR recruits the tyrosine kinase ZAP7, the microtubule-associated protein MAPT, thereby recruiting the associated LCK protein to the vicinity of the TCR/CD3 complex, ultimately leading to lymphokine production, which leads to hyperphosphorylation and activation of LCK, Non-receptor tyrosine-protein kinase that plays an essential role in the selection and maturation of developing T-cells in the thymus and in the function of mature T-cells |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Excitation Emission: |
675nm/694nm |
| Properties: |
Cy5 antibodies are excited by the 650-nanometer wave of an argon laser and detected at a 670-nanometer captor, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Conjugated: |
These antibodies are excite for emission at 678nm and detected at a 694 , nm wavelengths |
| Gene target: |
Lck/p56-LCK Conjugated |
| Short name: |
Conjugated, Lck/ -LCK Antibody |
| Technique: |
antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
5, Cy5 |
| Alternative name: |
cyanine 5, 5 coupled, lymphocyte-specific protein tyrosine kinase/p56-lymphocyte-specific protein tyrosine kinase (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
Cell surfaces, IMD22 and LSK and p56lck and pp58lck and YT16, LCK and IDBG-644592 and ENSBTAG00000012695 and 508890, LCK and IDBG-95667 and ENSG00000182866 and 3932, Lck and IDBG-191117 and ENSMUSG00000000409 and 16818, this GO :0000242 and pericentriolar material and cellular component this GO :0001772 and immunological synapse and cellular component this GO :0001948 and glycoprotein binding and molecular function this GO :0003823 and antigen binding and molecular function this GO :0004672 and protein kinase activity and molecular function this GO :0004713 and protein tyrosine kinase activity and molecular function this GO :0004715 and non-membrane spanning protein tyrosine kinase activity and molecular function this GO :0004722 and protein serine/threonine phosphatase activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005829 and cytosol and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0005911 and cell-cell junction and cellular component this GO :0006468 and protein phosphorylation and biological process this GO :0006882 and cellular zinc ion homeostasis and biological process this GO :0006915 and apoptotic process and biological process this GO :0006919 and activation of cysteine-type endopeptidase activity involved in apoptotic process and biological process this GO :0007166 and cell surface receptor signaling pathway and biological process this GO :0007173 and epidermal growth factor receptor signaling pathway and biological process this GO :0007568 and aging and biological process this GO :0007596 and blood coagulation and biological process this GO :0008022 and protein C-terminus binding and molecular function this GO :0008543 and fibroblast growth factor receptor signaling pathway and biological process this GO :0009612 and response to mechanical stimulus and biological process this GO :0010038 and response to metal ion and biological process this GO :0010043 and response to zinc ion and biological process this GO :0010628 and positive regulation of gene expression and biological process this GO :0016032 and viral process and biological process this GO :0016311 and dephosphorylation and biological process this GO :0016772 and transferase activity, this GO :0001948 : glycoprotein binding, this GO :0001948 : glycoprotein binding and also this GO :0003823 : antigen binding and also this GO :0004672 : protein kinase activity and also this GO :0004713 : protein tyrosine kinase activity and also this GO :0004715 : non-membrane spanning protein tyrosine kinase activity and also this GO :0004722 : protein serine/threonine phosphatase activity and also this GO :0005515 : protein binding and also this GO :0005524 : ATP binding and also this GO :0008022 : protein C-terminus binding and also this GO :0016772 : transferase activity, this GO :0003823 : antigen binding, this GO :0004672 : protein kinase activity, this GO :0004713 : protein tyrosine kinase activity, this GO :0004715 : non-membrane spanning protein tyrosine kinase activity, this GO :0004722 : protein serine/threonine phosphatase activity, this GO :0005515 : protein binding, this GO :0005524 : ATP binding, this GO :0008022 : protein C-terminus binding, this GO :0016772 : transferase activity, this GO :0019901 : protein kinase binding, this GO :0019903 : protein phosphatase binding, this GO :0032403 : protein complex binding, this GO :0042169 : SH2 domain binding, this GO :0042609 : CD4 receptor binding, this GO :0042610 : CD8 receptor binding, this GO :0042802 : identical protein binding, this GO :0043548 : phosphatidylinositol 3-kinase binding, this GO :0051117 : ATPase binding, transferase activity, transferring phosphorus-containing groups, transferring phosphorus-containing groups and also this GO :0019901 : protein kinase binding and also this GO :0019903 : protein phosphatase binding and also this GO :0032403 : protein complex binding and also this GO :0042169 : SH2 domain binding and also this GO :0042609 : CD4 receptor binding and also this GO :0042610 : CD8 receptor binding and also this GO :0042802 : identical protein binding and also this GO :0043548 : phosphatidylinositol 3-kinase binding and also this GO :0051117 : ATPase binding, transferring phosphorus-containing groups and molecular function this GO :0018108 and peptidyl-tyrosine phosphorylation and biological process this GO :0019901 and protein kinase binding and molecular function this GO :0019903 and protein phosphatase binding and molecular function this GO :0030097 and hemopoiesis and biological process this GO :0030139 and endocytic vesicle and cellular component this GO :0030168 and platelet activation and biological process this GO :0030217 and T cell differentiation and biological process this GO :0031295 and T cell costimulation and biological process this GO :0032403 and protein complex binding and molecular function this GO :0038095 and Fc-epsilon receptor signaling pathway and biological process this GO :0042169 and SH2 domain binding and molecular function this GO :0042493 and response to drug and biological process this GO :0042523 and positive regulation of tyrosine phosphorylation of Stat5 protein and biological process this GO :0042542 and response to hydrogen peroxide and biological process this GO :0042609 and CD4 receptor binding and molecular function this GO :0042610 and CD8 receptor binding and molecular function this GO :0042802 and identical protein binding and molecular function this GO :0043548 and phosphatidylinositol 3-kinase binding and molecular function this GO :0045087 and innate immune response and biological process this GO :0045121 and membrane raft and cellular component this GO :0045588 and positive regulation of gamma-delta T cell differentiation and biological process this GO :0046777 and protein autophosphorylation and biological process this GO :0048011 and neurotrophin TRK receptor signaling pathway and biological process this GO :0048015 and phosphatidylinositol-mediated signaling and biological process this GO :0050690 and regulation of defense response to virus by virus and biological process this GO :0050852 and T cell receptor signaling pathway and biological process this GO :0050853 and B cell receptor signaling pathway and biological process this GO :0050856 and regulation of T cell receptor signaling pathway and biological process this GO :0050862 and positive regulation of T cell receptor signaling pathway and biological process this GO :0050870 and positive regulation of T cell activation and biological process this GO :0050900 and leukocyte migration and biological process this GO :0051117 and ATPase binding and molecular function this GO :0051209 and release of sequestered calcium ion into cytosol and biological process this GO :0051249 and regulation of lymphocyte activation and biological process this GO :0070062 and extracellular vesicular exosome and cellular component this GO :0070474 and positive regulation of uterine smooth muscle contraction and biological process this GO :2001244 and positive regulation of intrinsic apoptotic signaling pathway and biological process, lymphocyte-specific protein tyrosine kinase |
| Identity: |
6524 |
| Gene: |
LCK |
More about : LCK |
| Long gene name: |
LCK proto-oncogene, Src family tyrosine kinase |
| Synonyms gene name: |
lymphocyte-specific protein tyrosine kinase |
| Locus: |
1p35, 2 |
| Discovery year: |
1986-01-01 |
| GenBank acession: |
M36881 |
| Entrez gene record: |
3932 |
| Pubmed identfication: |
2787474 |
| RefSeq identity: |
NM_005356 |
| Classification: |
SH2 domain containing Src family tyrosine kinases |
| Havana BLAST/BLAT: |
OTTHUMG00000007463 |
| Locus Specific Databases: |
LRG_153 |