| Long name: |
ALEXA FLUOR 350 Conjugated, LIS1 Polyclonal Antibody |
| Also known as: |
Anti-LIS1 PAb ALEXA FLUOR 350 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
350, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
LIS1 |
| Specificity: |
This is a highly specific antibody against LIS1 |
| Modification: |
Unmodified |
| Modification Site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human LIS1 |
| Gene ID Number: |
5048 |
| Swiss Prot: |
P43034 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
During nucleokinesis dynein at the nuclear surface may translocate the nucleus towards the centrosome by exerting force on centrosomal microtubules, May also play a role in other forms of cell locomotion including the migration of fibroblasts during wound healing, May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end, Neuronal migration involves a process called nucleokinesis, Non-catalytic subunit of an acetylhydrolase complex which inactivates platelet-activating factor (PAF) by removing the acetyl group at the SN-2 position (By similarity), Positively regulates the activity of the minus-end directed microtubule motor protein dynein, Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate, Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome, whereby migrating cells extend an anterior process into which the nucleus subsequently translocates, Required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA receptors |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
343nm/442nm |
| Synonyms: |
LIS1 PAFAH NudF |
| Properties: |
ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 350 conjugates can be used in multi-color flow cytometry with FACS's equipped with a second red laser or red diode, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
ALEXA FLUOR 350, Alexa Fluor |
| Gene target: |
LIS1 |
| Short name: |
LIS1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 350 |
| Alternative name: |
ALEXA FLUOR 350, LIS1 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
8574 |
| Gene: |
PAFAH1B1 |
More about : PAFAH1B1 |
| Long gene name: |
platelet activating factor acetylhydrolase 1b regulatory subunit 1 |
| Synonyms gene: |
MDCR MDS |
| Synonyms gene name: |
alpha subunit (45kD) Miller-Dieker syndrome chromosome region platelet-activating factor acetylhydrolase, alpha subunit 45kDa platelet-activating factor acetylhydrolase, isoform Ib, isoform Ib, isoform Ib, platelet-activating factor acetylhydrolase, regulatory subunit 1 (45kDa) , subunit 1 (45kDa) platelet-activating factor acetylhydrolase 1b |
| Synonyms name: |
lissencephaly-1 |
| Locus: |
17p13, 3 |
| Discovery year: |
1998-04-03 |
| GenBank acession: |
L25107 |
| Entrez gene record: |
5048 |
| Pubmed identfication: |
8355785 9063735 |
| RefSeq identity: |
NM_000430 |
| Classification: |
WD repeat domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000177574 |