| Long name: |
ALEXA FLUOR 647 Conjugated, WNK3 protein Polyclonal Antibody |
| Also known as: |
Anti-WNK3 protein PAb ALEXA FLUOR 647 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
647, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
WNK3 protein |
| Specificity: |
This is a highly specific antibody against WNK3 protein |
| Modification: |
Unmodified |
| Modification Site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
475-520/1800 |
| Subcellular location: |
Cytoplasm |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human WNK3 protein |
| Gene ID Number: |
65267 |
| Swiss Prot: |
Q9BYP7 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
According to PubMed:19470686, Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively, Increases Ca(2+) influx mediated by TRPV5 and TRPV6 by enhancing their membrane expression level via a kinase-dependent pathway, Inhibits the activity of KCNJ1 by decreasing its expression at the cell membrane in a non-catalytic manner, Isoform 1, Phosphorylates WNK4, Regulates the phosphorylation of SLC12A1 and SLC12A2, SLC12A2 and SLC12A3 and inhibit the activity of SLC12A4, SLC12A5, SLC12A6 and SLC12A7, cell signaling, isoform 1 inhibits the activity of SLC12A3, isoform 2, isoform 3 and isoform 4 stimulate the activity of SLC12A1, survival and proliferation, Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
650nm/665nm |
| Properties: |
ALEXA FLUOR made this Alexa Fluor 633 conjugate that can be used in multi-color flow cytometry with instruments equipped with a second red laser or red diode, ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 633 is a practical alternative to APC as well as Cy5, Bioss Primary Conjugated Antibodies, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, It is detected in the FL4 detector of the core's upgraded 2-laser FACScans, Like other Alexa Fluor dyes, exhibits uncommon photo stability, making it an ideal choice for fluorescent microscopy, the WNK3 protein Antibody, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
ALEXA FLUOR 647, Alexa Fluor |
| Gene target: |
WNK3 protein |
| Short name: |
WNK3 protein Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 647 |
| Alternative name: |
ALEXA FLUOR 647, WNK lysine deficient protein kinase 3 protein (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
Cell surfaces, WNK3 and IDBG-637533 and ENSBTAG00000023182 and, WNK3 and IDBG-71035 and ENSG00000196632 and 65267, Wnk3 and IDBG-178902 and ENSMUSG00000041245 and 279561, this GO :0004672 and protein kinase activity and molecular function this GO :0004674 and protein serine/threonine kinase activity and molecular function this GO :0004713 and protein tyrosine kinase activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005737 and cytoplasm and cellular component this GO :0005912 and adherens junction and cellular component this GO :0005923 and tight junction and cellular component this GO :0006468 and protein phosphorylation and biological process this GO :0010765 and positive regulation of sodium ion transport and biological process this GO :0010800 and positive regulation of peptidyl-threonine phosphorylation and biological process this GO :0016772 and transferase activity, this GO :0004672 : protein kinase activity, this GO :0004672 : protein kinase activity and also this GO :0004674 : protein serine/threonine kinase activity and also this GO :0004713 : protein tyrosine kinase activity and also this GO :0005515 : protein binding and also this GO :0005524 : ATP binding and also this GO :0016772 : transferase activity, this GO :0004674 : protein serine/threonine kinase activity, this GO :0004713 : protein tyrosine kinase activity, this GO :0005515 : protein binding, this GO :0005524 : ATP binding, this GO :0016772 : transferase activity, this GO :0019869 : chloride channel inhibitor activity, transferase activity, transferring phosphorus-containing groups, transferring phosphorus-containing groups and also this GO :0019869 : chloride channel inhibitor activity, transferring phosphorus-containing groups and molecular function this GO :0019869 and chloride channel inhibitor activity and molecular function this GO :0032414 and positive regulation of ion transmembrane transporter activity and biological process this GO :0035556 and intracellular signal transduction and biological process this GO :0043066 and negative regulation of apoptotic process and biological process this GO :0046777 and protein autophosphorylation and biological process this GO :0051928 and positive regulation of calcium ion transport and biological process this GO :0090004 and positive regulation of establishment of protein localization to plasma membrane and biological process this GO :2000021 and regulation of ion homeostasis and biological process this GO :2000651 and positive regulation of sodium ion transmembrane transporter activity and biological process this GO :2000682 and positive regulation of rubidium ion transport and biological process this GO :2000688 and positive regulation of rubidium ion transmembrane transporter activity and biological process, WNK lysine deficient protein kinase 3 |
| Identity: |
14543 |
| Gene: |
WNK3 |
More about : WNK3 |
| Long gene name: |
WNK lysine deficient protein kinase 3 |
| Synonyms gene: |
PRKWNK3 |
| Synonyms gene name: |
lysine deficient 3 , protein kinase |
| Locus: |
Xp11, 22 |
| Discovery year: |
2001-02-07 |
| GenBank acession: |
AJ409088 |
| Entrez gene record: |
65267 |
| RefSeq identity: |
NM_020922 |
| Havana BLAST/BLAT: |
OTTHUMG00000021626 |
| Locus Specific Databases: |
Mental Retardation database |