MMP-8 Antibody

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Catalog number: bs-1913R
Price: 263 €
Supplier: Bioss Primary Unconjugated Antibodies
Product name: MMP-8 Antibody
Quantity: 0.1ml
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Long name: MMP-8 Primary Polyclonal Antibody
Also known as: MMP-8 PAb
Category: Primary Antibodies
Conjugation: Unconjugated
Target Antigen: MMP-8
Specificity: This is a highly specific antibody against MMP-8
Modification(s): None
Modification site(s): Unmodified antibody
Clonality: Polyclonal antibody
Clone number: Polyclonal antibody
Concentration: 1ug per 1ul
Immunogen range: 262-312/467
Subcellular location: Secreted, Extracellular
Source: This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human MMP8
Gene ID number: 4317
Swiss Prot: P22894
Tested Applications: IF(IHC-P), IHC-P, WB
Recommended dilutions: IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity: Mouse, Rat, Human
Cross reactive species details: not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen: All collagenases cleave fibrillar collagens at one specific site resulting in generation of N terminal three quarter and C terminal one quarter fragments, II, III, MMP13, MMP8 degrades fibrillar collagens types I, MMP8 is heavily glycosylated, MMP8 is very similar to MMP1, Most cell types do not produce MMP8, The human MMP8 gene has the chromosomal location of 11q22, The substrate specificity of collagenases is variable: MMP1 degrades type III collagen more efficiently than type I or type II collagen, The zymogen is quickly activated to the 64 Kd form, Until recently, aggrecan, and the zymogen has a mass of 85 Kd, and this breaks down to a cascade of active forms, but it has also been detected in other cell types including arthritic chondrocytes and gingival fibroblasts, in turn degrades type II collagen 6 fold more efficiently than type I and type II collagens and displays almost 50 fold stronger gelatinolytic activity than MMP1 and MMP8, it was thought that MMP8 was produced exclusively by neutrophils, serpins and alpha 2 macroglobulin, sharing 57 % amino acid identity, whereas MMP8 is more potent in degrading type I collagen than type III or type II collagen, which then denature to gelatin at body temperature, 2-22, 3, Matrix Metalloproteinase 8 (MMP8) is also known as neutrophil collagenase and collagenase 2
Purification method: This antibody was purified via Protein A
Storage conditions: 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names: CLG1, MMP-8, MMP8, Matrix metalloproteinase-8, Neutrophil collagenase, PMNL collagenase, PMNL-CL, HNC
Properties: C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene target: MMP-8
Short name: MMP-8 Antibody
Technique: antibodies against human proteins, antibodies for, Antibody
Alternative name: MMP-8 (Antibody to)
Alternative technique: antibodies

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