| Long name: |
Cy3 Conjugated, EPH receptor A4 Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
cy3 conjugation kit |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
EPH receptor A4 |
| Specificity: |
This is a highly specific antibody against EPH receptor A4 |
| Modification: |
Unmodified |
| Modification site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen_range: |
570-620/986 |
| Subcellular location: |
Cytoplasm |
| Source: |
KLH conjugated synthetic peptide derived from human EphA4 |
| Gene ID number: |
2043 |
| Swiss Prot: |
P54764 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
Activated by EFNA1 phosphorylates CDK5 at 'Tyr-15' which in turn phosphorylates NGEF regulating RHOA and dendritic spine morphogenesis, Additionally, Highly promiscuous, In addition to its role in axonal guidance plays a role in synaptic plasticity, In the nervous system, May also control the segregation of motor and sensory axons during neuromuscular circuit development, Plays an important role in the development of the nervous system controlling different steps of axonal guidance including the establishment of the corticospinal projections, Rap and Rho GTPases activity, The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling, Upon activation by ephrin ligands, it has the unique property among Eph receptors to bind and to be physiologically activated by both GPI-anchored ephrin-A and transmembrane ephrin-B ligands including EFNA1 and EFNB3, its promiscuity makes it available to participate in a variety of cell-cell signaling regulating for instance the development of the thymic epithelium, leading to contact-dependent bidirectional signaling into neighboring cells, modulates cell morphology and integrin-dependent cell adhesion through regulation of the Rac, plays also a role in repair after injury preventing axonal regeneration and in angiogenesis playing a role in central nervous system vascular formation, Receptor tyrosine kinase which binds membrane-bound ephrin family ligands residing on adjacent cells |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Excitation Emission: |
512, 550nm/570, 615nm |
| Synonyms: |
EPH |
| Properties: |
1 of the EPH receptor A4 Antibody, Conjugated can be used in flow cytometry but typically shows lower fluorescence intensity comparable to that of PE or APC, Cy3 antibodies are excited by the 488-nanometer wave of an argon laser and the 633-nanometer line of a helium-neon diode laser, This Bioss Primary Conjugated Antibodies antibody is well suited for fluorescent microscopy, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Description: |
2 or 3 and , However, In this sense, When such chemical-signals couple or bind to a receptor, a change in the electrical-activity of a cell, acetylcholine, am olfactory receptor is a protein-molecule that recognizes and responds to , an acetylcholine-receptor recognizes and responds to its endogenous-ligand, chemokinesor cytokines e, e, sometimes in pharmacology, such as enzymes, the term is also used to include other proteins that are drug-targets, they cause some form of cellular/tissue-response, transporters and ion-channels, The receptors are ligand binding factors of type 1, endogenous-chemical signals, g, g, protein-molecules , that receive chemical-signals from outside a cell |
| Gene target: |
EPH receptor A4 Conjugated |
| Short name: |
Conjugated, EPH receptor A4 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
Cy3 |
| Alternative name: |
cyanine 3 coupled, EPH receptor A4 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
3385 |
| Gene: |
EPHA1 |
More about : EPHA1 |
| Long gene name: |
EPH receptor A1 |
| Synonyms gene: |
EPHT EPHT1 |
| Synonyms gene name: |
EphA1 |
| Locus: |
7q34-q35 |
| Discovery year: |
1989-05-16 |
| GenBank acession: |
M18391 |
| Entrez gene record: |
2041 |
| Pubmed identfication: |
9267020 |
| Classification: |
Sterile alpha motif domain containing Fibronectin type III domain containing EPH receptors |
| Havana BLAST/BLAT: |
OTTHUMG00000155894 |