MEK1/MAPKK1(Ser298) Antibody, ALEXA FLUOR 555

Catalog number:	bs-1736R-A555 Buy Now
Price:	332 €
Supplier:	Bioss Primary Conjugated Antibodies.
Product name:	MEK1/MAPKK1(Ser298) Antibody, ALEXA FLUOR 555
Quantity:	100ul
Related search:	alexa gene mapkerk kinase cascade kinases the

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Long name:	ALEXA FLUOR 555 Conjugated, MEK1/MAPKK1(Ser298) Polyclonal Antibody
Also known as:	Anti-MEK1/MAPKK1 Ser298 PAb ALEXA FLUOR 555
Category:	Conjugated Primary Antibodies
Conjugated with:	555, ALEXA FLUOR®
Host Organism:	Rabbit (Oryctolagus cuniculus)
Target Antigen:	MEK1/MAPKK1 Ser298
Specificity:	This is a highly specific antibody against MEK1/MAPKK1 Ser298
Modification:	Phosphorylation
Modification Site:	Ser298
Clonality:	Polyclonal
Clone:	Polyclonal antibody
Concentration:	1ug per 1ul
Immunogen range:	276-309/393
Source:	KLH conjugated synthetic phosphopeptide derived from human MAPKK1 around the phosphorylation site of Ser298
Gene ID Number:	5604
Swiss Prot:	Q02750
Tested applications:	IF(IHC-P)
Recommended dilutions:	IF(IHC-P)(1:50-200)
Crossreactivity:	Mouse, Human
Cross-reactive species details:	not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the antigen:	Binding of extracellular ligands such as growth factors, Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, Depending on the cellular context, MAP2K1/MEK1 has been shown to export PPARG from the nucleus, One target of the MAPK/ERK cascade is peroxisome proliferator-activated receptor gamma (PPARG), RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2, The MAPK/ERK cascade is also involved in the regulation of endosomal dynamics, a nuclear receptor that promotes differentiation and apoptosis, adhesion, and catalyze the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2, as well as in the fragmentation of the Golgi apparatus during mitosis, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC), leading to their activation and further transduction of the signal within the MAPK/ERK cascade, metabolism and cytoskeletal rearrangements, predominantly through the regulation of transcription, survival and differentiation, this pathway mediates diverse biological functions such as cell growth, Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway
Purification:	Purified by Protein A
Storage conditions:	50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA
Excitation emission:	553nm/568nm
Synonyms:	MEK1 MAPKK1
Properties:	ALEXA FLUOR they should be stored frozen at - 24°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, Very high photo stable ALEXA conjugate, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate
Conjugation:	ALEXA FLUOR 555, Alexa Fluor
Gene target:	MEK1/MAPKK1(Ser298)
Short name:	MEK1/MAPKK1(Ser298) Antibody
Technique:	antibodies against human proteins, antibodies for, Antibody
Label:	ALEXA FLUOR 555
Alternative name:	ALEXA FLUOR 555, MEK1/MAPKK1(Ser298) (Antibody to)
Alternative technique:	antibodies
Identity:	6840
Gene:	MAP2K1 | More about : MAP2K1
Long gene name:	mitogen-activated protein kinase kinase 1
Synonyms gene:	PRKMK1
Locus:	15q22, 31
Discovery year:	1993-11-05
GenBank acession:	L11284
Entrez gene record:	5604
Pubmed identfication:	9465908 8388392
Classification:	Mitogen-activated protein kinase kinases
Havana BLAST/BLAT:	OTTHUMG00000133196
Locus Specific Databases:	The Globin Gene Server LRG_725

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