| Long name: |
CD146 Primary Polyclonal Antibody |
| Also known as: |
CD146 PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
CD146/MCAM |
| Specificity: |
This is a highly specific antibody against CD146/MCAM |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
200-250/646 |
| Subcellular location: |
Extracellular |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human CD146 |
| Gene ID number: |
4162 |
| Swiss Prot: |
P43121 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, Could be an adhesion molecule active in neural crest cells during embryonic development, Its expression may allow melanoma cells to interact with cellular elements of the vascular system, and a transient increase in the intracellular calcium concentration, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue, thereby enhancing hematogeneous tumor spread, Plays a role in cell adhesion |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
Cell surface glycoprotein MUC18, Cell surface glycoprotein P1H12, MCAM, MUC18, Melanoma cell adhesion molecule, Melanoma-associated antigen A32, Melanoma-associated antigen MUC18, S-endo 1 endothelial-associated antigen, CD146 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
CD146 |
| Short name: |
CD146 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
CD146 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
6934 |
| Gene: |
MCAM |
More about : MCAM |
| Long gene name: |
melanoma cell adhesion molecule |
| Synonyms: |
MUC18 CD146 |
| Synonyms name: |
Gicerin |
| Locus: |
11q23, 3 |
| Discovery year: |
1995-12-18 |
| GenBank acession: |
X68264 |
| Entrez gene record: |
4162 |
| Pubmed identfication: |
2602381 10702685 |
| Classification: |
C2-set domain containing CD molecules V-set domain containing Immunoglobulin like domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000166197 |