| Long name: |
MTA1 Primary Polyclonal Antibody |
| Also known as: |
MTA1 PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
MTA1 |
| Specificity: |
This is a highly specific antibody against MTA1 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
650-700/715 |
| Subcellular location: |
Nucleus |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human MTA1 |
| Gene ID number: |
9112 |
| Swiss Prot: |
Q13330 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Acts as a transcriptional coactivator of BCAS3, As a part of the histone-deacetylase multiprotein complex (NuRD), ESR1, IFI16 and HDAC4/5/6-dependent manner, In conjunction with other components of NuRD, Involved in the epigenetic regulation of ESR1 expression in breast cancer in a TFAP2C, Isoform Short binds to ESR1 and sequesters it in the cytoplasm and enhances its non-genomic responses, MIP2, PAX5 and SUMO2, Plays a role in the inflammatory responses, Plays a role in the regulation of the circadian clock and is essential for the generation and maintenance of circadian rhythms under constant light and for normal entrainment of behavior to light-dark (LD) cycles, Plays an important role in tumorigenesis, Positively regulates the CLOCK-ARNTL/BMAL1 heterodimer mediated transcriptional activation of its own transcription and the transcription of CRY1, Regulates deacetylation of ARNTL/BMAL1 by regulating SIRT1 expression, Regulates p53-dependent and -independent DNA repair processes following genotoxic stress, Regulates the stability and function of p53/TP53 by inhibiting its ubiquitination by COP1 and MDM2 thereby regulating the p53-dependent DNA repair, Stimulates the expression of WNT1 by inhibiting the expression of its transcriptional corepressor SIX3, TFF1 and CDKN1A, acts as a transcriptional corepressor of BRCA1, and TNF, and metastasis, both as a target and as a component of the NF-kappa-B signaling and regulates a subset of proinflammatory cytokines such as IL1B, independent of the NuRD complex, regulates transcription of its targets by modifying the acetylation status of the target chromatin and cofactor accessibility to the target DNA, resulting in derepressing CRY1-mediated transcription repression, tumor invasion, Transcriptional coregulator which can act as both a transcriptional corepressor and coactivator |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
MTA1, Metastasis-associated protein MTA1 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
MTA1 |
| Short name: |
MTA1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
MTA1 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
7410 |
| Gene: |
MTA1 |
More about : MTA1 |
| Long gene name: |
metastasis associated 1 |
| Locus: |
14q32, 33 |
| Discovery year: |
1999-03-12 |
| GenBank acession: |
U35113 |
| Entrez gene record: |
9112 |
| Pubmed identfication: |
8083195 7607577 |
| Classification: |
GATA zinc finger domain containing NuRD complex Myb/SANT domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000150362 |