| Long name: |
CDK9 Primary Polyclonal Antibody |
| Also known as: |
CDK9 PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
CDK9 |
| Specificity: |
This is a highly specific antibody against CDK9 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
250-300/372 |
| Subcellular location: |
Nucleus, Cytoplasm |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human CDK9 |
| Gene ID number: |
1025 |
| Swiss Prot: |
P50750 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
AR phosphorylation modulates AR transcription factor promoter selectivity and cell growth, H3 lysine 4 trimethylation (H3K4me3) and H3K36me3, In addition, MYOD1, Member of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex, Modulates a complex network of chromatin modifications including histone H2B monoubiquitination (H2Bub1), P-TEFb is also involved in cotranscriptional histone modification, Phosphorylates EP300, Promotes RNA synthesis in genetic programs for cell growth, Promotes cardiac myocyte enlargement, RPB1/POLR2A and AR, RPB1/POLR2A phosphorylation on 'Ser-2' in CTD activates transcription, Regulates cytokine inducible transcription networks by facilitating promoter recognition of target transcription factors (e, Replication stress response protein, SUPT5H and RDBP, TNF-inducible RELA/p65 activation and IL-6-inducible STAT3 signaling), The CDK9/cyclin-K complex has also a kinase activity towards CTD of RNAP II and can substitute for CDK9/cyclin-T P-TEFb in vitro, This complex is inactive when in the 7SK snRNP complex form, also called positive transcription elongation factor b (P-TEFb), and the negative elongation factors DSIF and NELF, by promoting cell cycle recovery from replication arrest and limiting single-stranded DNA amount in response to replication stress, differentiation and viral pathogenesis, integrates phosphorylation during transcription with chromatin modifications to control co-transcriptional histone mRNA processing, mRNA processing and mRNA export, probable function in DNA repair of isoform 2 via interaction with KU70/XRCC6, the CDK9/cyclin-K complex is required for genome integrity maintenance, thus reducing the breakdown of stalled replication forks and avoiding DNA damage, which facilitates the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) POLR2A, Protein kinase involved in the regulation of transcription, g |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
C-2k, CDC2L4, CDK9, CTK1, Cell division cycle 2-like protein kinase 4, Cell division protein kinase 9, Cyclin-dependent kinase 9, PITALRE, Serine/threonine-protein kinase PITALRE, Tat-associated kinase complex catalytic subunit, TAK |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
CDK9 |
| Short name: |
CDK9 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
CDK9 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
1780 |
| Gene: |
CDK9 |
More about : CDK9 |
| Long gene name: |
cyclin dependent kinase 9 |
| Synonyms gene: |
CDC2L4 |
| Synonyms gene name: |
cyclin-dependent kinase 9 (CDC2-related kinase) |
| Synonyms: |
PITALRE C-2k TAK |
| Locus: |
9q34, 11 |
| Discovery year: |
1998-04-29 |
| GenBank acession: |
L25676 |
| Entrez gene record: |
1025 |
| Pubmed identfication: |
8170997 9356449 |
| Classification: |
Cyclin dependent kinases P-TEFb complex |
| Havana BLAST/BLAT: |
OTTHUMG00000020715 |