| Long name: |
FOX C2 Primary Polyclonal Antibody |
| Also known as: |
FOX C2 PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
FOX C2 |
| Specificity: |
This is a highly specific antibody against FOX C2 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human FOX C2 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
FOXC2 expression is also associated with the early stage of chondrogenic differentiation both in vivo and in vitro (3), FOXC2 functions as a key regulator of adipocyte metabolism by increasing the sensitivity of the beta-adrenergic-cAMP-protein kinase A (PKA) signaling pathway through alteration of adipocyte PKA holoenzyme composition (4), FOXC2 haploinsufficiency results in Lymphedema-distichiasis (LD), FOXC2 interacts with FOXC1 in the Notch signaling pathway (1) and in kidney and heart development (2), Increased FOXC2 levels, Mutant mice null for FOXC2 show defects in axial and cranial skeletogenesis, an autosomal dominant disorder that classically presents as lymphedema of the limbs, and double rows of eyelashes (distichiasis) (5), induced by high fat diet, seem to counteract most of the symptoms associated with obesity (4), suggesting a requirement of FOXC2 for skeletal tissue development (3), whose members serve as key regulators in embryogenesis and cell differentiation (3), FOXC2 is a member of forkhead/winged helix transcription factor family |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
Drosphilia Forkhead Homolog Like 14, FKHL 14, FKHL 14, FKHL14, FOX C2, FOXC2_HUMAN, Forkhead Box C2, Forkhead Box C2, Forkhead box protein C2, Forkhead related protein FKHL14, Forkhead-related protein FKHL14, Foxc2, LD, MFH 1, MFH 1, MFH 1 protein, MFH-1 protein, MFH1, Mesenchyme Forkhead 1, Mesenchyme Forkhead 1, Mesenchyme fork head protein 1, Transcription factor FKH 14, Transcription factor FKH-14, Drosphilia Forkhead Homolog Like 14 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
FOX C2 |
| Short name: |
FOX C2 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
FOX complement component 2 (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
ARMD14 and CO2, C2 and IDBG-124824 and ENSG00000166278 and 101928623, C2 and IDBG-174547 and ENSMUSG00000024371 and 12263, C2 and IDBG-633680 and ENSBTAG00000007450 and 515440, Extracellular, classical pathway and biological process this GO :0007584 and response to nutrient and biological process this GO :0030449 and regulation of complement activation and biological process this GO :0045087 and innate immune response and biological process this GO :2000427 and positive regulation of apoptotic cell clearance and biological process, protein binding, this GO :0003824 and catalytic activity and molecular function this GO :0004252 and serine-type endopeptidase activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005576 and extracellular region and cellular component this GO :0005615 and extracellular space and cellular component this GO :0006508 and proteolysis and biological process this GO :0006956 and complement activation and biological process this GO :0006958 and complement activation, this GO :0003824 : catalytic activity, this GO :0003824 : catalytic activity and also this GO :0004252 : serine-type endopeptidase activity and also this GO :0005515 : protein binding, this GO :0004252 : serine-type endopeptidase activity, this GO :0005515 : protein binding, 717, complement component 2 |